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The Prognostic Significance of HER2 Positivity for Advanced Gastric Cancer Patients Undergoing First-line Modified FOLFOX-6 Regimen
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin Won | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Miso | - |
dc.contributor.author | Cha, Yongjun | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Min A. | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T11:01:12Z | - |
dc.date.available | 2021-01-31T11:01:12Z | - |
dc.date.created | 2020-12-16 | - |
dc.date.created | 2020-12-16 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | Anticancer Research, Vol.32 No.4, pp.1547-1553 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.other | 119228 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172969 | - |
dc.description.abstract | Aim: We aimed to clarify the prognostic significance of HER2 positivity in advanced gastric cancer. Patients and Methods: The cohort included patients with initially metastatic or recurrent gastric cancer treated with first-line modified FOLFOX-6. The HER2 status was analyzed according to modified scoring criteria specific for gastric cancer. Results: HER2 positivity was shown in 10 out of 114 patients (9.0%). The median time-to-progression (TTP) (4.3 months, 95% confidence interval (CI)=3.6-4.9) and the overall survival (OS) (7.5 months, 95% CI=6.1-8.8) of patients with HER2-positive gastric cancer tended to be shorter than the median TTP (5.9 months, 95% CI=4.5-7.2) and OS (10.8 months, 95% CI=9.2-12.3) of those with HER2-negative gastric cancer (TTP, p=0.177; OS, p=0.068). Particularly in the subgroup of patients without diffuse-type histology, HER2-positive gastric cancer had a worse TTP than those with HER2-negative gastric cancer (p=0.024). In multivariate analysis of this subgroup, HER2 positivity and ECOG performance status of 2 were associated with shorter TTP (hazard ratio (HR)=2.926, p=0.014; HR=2.489, p=0.035, respectively). Conclusion: HER2-positive gastric cancer seems to confer poorer prognosis, particularly in patients without diffuse-type tumor, treated with modified FOLFOX-6. | - |
dc.language | 영어 | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | The Prognostic Significance of HER2 Positivity for Advanced Gastric Cancer Patients Undergoing First-line Modified FOLFOX-6 Regimen | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.citation.journaltitle | Anticancer Research | - |
dc.identifier.wosid | 000302492600060 | - |
dc.identifier.scopusid | 2-s2.0-84859992169 | - |
dc.citation.endpage | 1553 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1547 | - |
dc.citation.volume | 32 | - |
dc.identifier.sci | 000302492600060 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Kim, Woo Ho | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ADVANCED ESOPHAGOGASTRIC CANCER | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | TRASTUZUMAB | - |
dc.subject.keywordPlus | C-ERBB-2 | - |
dc.subject.keywordPlus | CAPECITABINE | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordAuthor | HER2 positivity | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | FOLFOX-6 regimen | - |
dc.subject.keywordAuthor | FISH | - |
dc.subject.keywordAuthor | transtuzumab | - |
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