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A phase III randomized trial of 5-fluorouracil, doxorubicin, and mitomycin C versus 5-fluorouracil and mitomycin C versus 5-fluorouracil alone in curatively resected gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Chang, HM | - |
dc.contributor.author | Jung, KH | - |
dc.contributor.author | Kim, TY | - |
dc.contributor.author | Kim, WS | - |
dc.contributor.author | Yang, HK | - |
dc.contributor.author | Lee, KU | - |
dc.contributor.author | Choe, KJ | - |
dc.contributor.author | Heo, DS | - |
dc.contributor.author | Bang, YJ | - |
dc.contributor.author | Kim, NK | - |
dc.date.accessioned | 2021-01-31T11:02:36Z | - |
dc.date.available | 2021-01-31T11:02:36Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2002-11 | - |
dc.identifier.citation | Annals of Oncology, Vol.13 No.11, pp.1779-1785 | - |
dc.identifier.issn | 0923-7534 | - |
dc.identifier.other | 119630 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172986 | - |
dc.description.abstract | Background: A phase III single-center randomized trial was performed in order to determine whether the addition of mitomycin C (MMC) and/or doxorubicin to 5-fluorouracil (5-FU) as adjuvant chemotherapy could influence survival in patients with curatively resected gastric cancer. Patients and methods: A total of 416 patients who had undergone curative resection for stage IB-IIIB gastric adenocarcinoma were stratified according to the stage and type of surgery, and then randomized to receive one of the three chemotherapy regimens, 5-FU alone (F) or 5-FU and MMC (FM) or 5-FU, doxorubicin and MMC (FAM) within 5 weeks after surgery. Results: Of 416 patients registered, 395 (133 in F, 131 in FM and 131 in FAM) were assessable. Median follow-up duration was 91 months. Five-year overall survival rates were 67.2% for F, 67.0% for FM and 66.7% for FAM (P = 0.97). Five-year disease-free survival rates were 62.1% for F, 63.3% for FM and 62.5% for FAM (P = 0.83). Hematological toxicities were more frequent in the FM and FAM groups, whereas stomatitis was more common in the F group. Conclusions: Compared with adjuvant 5-FU alone, the addition of MMC and/or doxorubicin to 5-FU did not influence survival in patients with resected gastric cancer. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | A phase III randomized trial of 5-fluorouracil, doxorubicin, and mitomycin C versus 5-fluorouracil and mitomycin C versus 5-fluorouracil alone in curatively resected gastric cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1093/annonc/mdf302 | - |
dc.citation.journaltitle | Annals of Oncology | - |
dc.identifier.wosid | 000179453600012 | - |
dc.identifier.scopusid | 2-s2.0-0036860299 | - |
dc.citation.endpage | 1785 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 1779 | - |
dc.citation.volume | 13 | - |
dc.identifier.sci | 000179453600012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, TY | - |
dc.contributor.affiliatedAuthor | Yang, HK | - |
dc.contributor.affiliatedAuthor | Lee, KU | - |
dc.contributor.affiliatedAuthor | Choe, KJ | - |
dc.contributor.affiliatedAuthor | Heo, DS | - |
dc.contributor.affiliatedAuthor | Bang, YJ | - |
dc.contributor.affiliatedAuthor | Kim, NK | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POSTOPERATIVE ADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | FAM | - |
dc.subject.keywordAuthor | adjuvant chemotherapy | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | 5-fluorouracil | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | mitomycin C | - |
dc.subject.keywordAuthor | phase III trial | - |
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