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Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway

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dc.contributor.authorYun, Jeanho-
dc.contributor.authorChae, Hee-Don-
dc.contributor.authorChoi, Tae-Saeng-
dc.contributor.authorKim, Eun-Hee-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorChung, JongkyeongK-
dc.contributor.authorChoi, Kyeong-Sook-
dc.contributor.authorMantovani, Roberto-
dc.contributor.authorShin, Deug Y.-
dc.date.accessioned2021-01-31T11:03:17Z-
dc.date.available2021-01-31T11:03:17Z-
dc.date.issued2003-09-
dc.identifier.citationJournal of Biological Chemistry, Vol.278 No.38, pp.36966-36972-
dc.identifier.issn0021-9258-
dc.identifier.other119609-
dc.identifier.urihttps://hdl.handle.net/10371/172990-
dc.description.abstractRecent studies have suggested that the NF-Y transcription factor is involved in transcription repression of the cell cycle regulatory genes in a response to p53 induction or DNA damage. Here we demonstrate the cdk2-dependent phosphorylation of NF-Y and its involvement in transcription repression by the p53-p21 signaling pathway. Cdk2 phosphorylates two serine residues near the DNA-binding domain of the YA subunit of NF-Y. Cyclin A-cdk2 appears to associate with NF-Y both in vitro and in vivo. Furthermore, YA protein is phosphorylated in parallel with a cell cycle-dependent activation of cdk2 kinase and cyclin A expression. YA phosphorylation is unnecessary for heterotrimer formation with the YB-YC dimer. However, NF-Y containing a phosphorylation-deficient mutant form of YA, YA-aa, has its DNA binding activity impaired. Consistently, YA-aa inhibits transcription activation of a NF-Y target promoter, cdc2, by cdk2. These results facilitate the elucidation of the regulatory mechanisms of cell cycle progression involving the p21-cdk2-NF-Y signaling pathway.-
dc.titleCdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1074/jbc.M305178200-
dc.citation.journaltitleJournal of Biological Chemistry-
dc.identifier.scopusid2-s2.0-0141591674-
dc.citation.endpage36972-
dc.citation.number38-
dc.citation.startpage36966-
dc.citation.volume278-
dc.identifier.urlhttps://www.jbc.org/content/278/38/36966-
dc.identifier.rimsid119609-
dc.identifier.sci000185318300131-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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