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Prognostic factors for recurrent breast cancer patients with an isolated, limited number of lung metastases and implications for pulmonary metastasectomy
DC Field | Value | Language |
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dc.contributor.author | Yhim, Ho-Young | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Kim, Young Tae | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Ha, Sung Whan | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T11:04:44Z | - |
dc.date.available | 2021-01-31T11:04:44Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2010-06-15 | - |
dc.identifier.citation | Cancer, Vol.116 No.12, pp.2890-2901 | - |
dc.identifier.issn | 0008-543X | - |
dc.identifier.other | 119696 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173008 | - |
dc.description.abstract | BACKGROUND: The aim of this study was to evaluate the clinical treatment outcomes of recurrent breast cancer with a limited number of isolated lung metastases, and to evaluate the role of pulmonary metastasectorny. METHODS: The authors consecutively enrolled 140 recurrent breast cancer patients with isolated lung metastasis from 1997 to 2007 in Seoul National University Hospital and retrospectively analyzed 45 patients who had <4 metastatic lesions. RESULTS: Fifteen patients had pulmonary metastasectomy followed by systemic treatment (pulmonary metastasectomy group), and 30 received systemic treatment alone (nonpulmonary metastasectomy group). The 3-year progression-free survival (PFS) and 4-year overall survival (OS) was significantly longer in the pulmonary metastasectomy group than in the nonpulmonary metastasectomy group (3-year PFS, 55.0% vs 4.5%, P <.001; 4-year OS, 82.1% vs 31.6%, P = .001). In multivariate analysis, a disease-free interval (DFI) of <24 months (hazard ratio [HP], 4.53; 95% CI, 1.72-11.90), no pulmonary metastasectomy (HR, 9.52; 95% Cl, 3.34-27.18) and biologic subtypes such as human epithelial growth factor receptor-2 positive (HR, 3.00; 95% Cl, 1.04-8.64) and triple negative (HR, 3.92; 95% Cl, 1.32-11.59) were independent prognostic factors for shorter PFS. CONCLUSIONS: The authors' results demonstrated that DFI and biologic subtypes of tumor are firm, independent, prognostic factors for survival, and pulmonary metastasectomy can be a reasonable treatment option in this population. Further prospective studies are warranted to evaluate the role of pulmonary metastasectomy. Cancer 2010;116:2890-901. (C) 2010 American Cancer Society. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Prognostic factors for recurrent breast cancer patients with an isolated, limited number of lung metastases and implications for pulmonary metastasectomy | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1002/cncr.25054 | - |
dc.citation.journaltitle | Cancer | - |
dc.identifier.wosid | 000278665900010 | - |
dc.identifier.scopusid | 2-s2.0-77954019311 | - |
dc.citation.endpage | 2901 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 2890 | - |
dc.citation.volume | 116 | - |
dc.identifier.sci | 000278665900010 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Han, Wonshik | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Noh, Dong-Young | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Ha, Sung Whan | - |
dc.contributor.affiliatedAuthor | Park, In Ae | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RENAL-CELL CARCINOMA | - |
dc.subject.keywordPlus | CLINICOPATHOLOGICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | CONTAINING CHEMOTHERAPY | - |
dc.subject.keywordPlus | SURGICAL RESECTION | - |
dc.subject.keywordPlus | SOFT-TISSUE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | SARCOMA | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | lung metastasis | - |
dc.subject.keywordAuthor | prognostic factors | - |
dc.subject.keywordAuthor | pulmonary metastasectomy | - |
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