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Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Seongyeong | - |
dc.contributor.author | Min, Ahrum | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Yang, Yaewon | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Lim, Jee Min | - |
dc.contributor.author | Park, So Jung | - |
dc.contributor.author | Nam, Hyun-Jin | - |
dc.contributor.author | Kim, Jung Eun | - |
dc.contributor.author | Song, Sang-Hyun | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Hangauer, David | - |
dc.contributor.author | Lau, Johnson Yiu-Nam | - |
dc.contributor.author | Im, Kyongok | - |
dc.contributor.author | Lee, Dong Soon | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.date.accessioned | 2021-01-31T11:11:57Z | - |
dc.date.available | 2021-01-31T11:11:57Z | - |
dc.date.created | 2018-09-14 | - |
dc.date.created | 2018-09-14 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | Cancer Research and Treatment, Vol.49 No.3, pp.643-655 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.other | 53886 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173101 | - |
dc.description.abstract | Purpose KX-01 is a novel dual inhibitor of Src and tubulin. Unlike previous Src inhibitors that failed to show clinical benefit during treatment of breast cancer, KX-01 can potentially overcome the therapeutic limitations of current Src inhibitors through inhibition of both Src and tubulin. The present study further evaluates the activity and mechanism of KX-01 in vitro and in vivo. Materials and Methods The antitumor effect of KX-01 in triple negative breast cancer (TNBC) cell lines was determined by MU assay. Wound healing and immunofluorescence assays were performed to evaluate the action mechanisms of KX-01. Changes in the cell cycle and molecular changes induced by KX-01 were also evaluated. A MDA-MB-231 mouse xenograft model was used to demonstrate the in vivo effects. Results KX-01 effectively inhibited the growth of breast cancer cell lines. The expression of phos-pho-Src and proliferative-signaling molecules were down-regulated in KX-01-sensitive TNBC cell lines. In addition, migration inhibition was observed by wound healing assay. KX-01-induced G2/M cell cycle arrest and increased the aneuploid cell population in KX-01-sensitive cell lines. Multi-nucleated cells were significantly increased after KX-01 treatment. Furthermore, KX-01 effectively delayed tumor growth in a MDA-MB-231 mouse xenograft model. Conclusion KX-01 effectively inhibited cell growth and migration of TNBC cells. Moreover, this study demonstrated that KX-01 showed antitumor effects through the inhibition of Src signaling and the induction of mitotic catastrophe. The antitumor effects of KX-01 were also demonstrated in vivo using a mouse xenograft model. | - |
dc.language | 영어 | - |
dc.publisher | 대한암학회 | - |
dc.title | Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.4143/crt.2016.168 | - |
dc.citation.journaltitle | Cancer Research and Treatment | - |
dc.identifier.wosid | 000405537800010 | - |
dc.identifier.scopusid | 2-s2.0-85022018760 | - |
dc.citation.endpage | 655 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 643 | - |
dc.citation.volume | 49 | - |
dc.identifier.sci | 000405537800010 | - |
dc.identifier.kciid | ART002243188 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Lee, Dong Soon | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NEGATIVE BREAST-CANCER | - |
dc.subject.keywordPlus | MITOTIC CATASTROPHE | - |
dc.subject.keywordPlus | SARACATINIB AZD0530 | - |
dc.subject.keywordPlus | TARGETING SRC | - |
dc.subject.keywordPlus | PHASE-II | - |
dc.subject.keywordPlus | TUBULIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CYTOKINESIS | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Src kinase inhibitor | - |
dc.subject.keywordAuthor | Mitotic catastrophe | - |
dc.subject.keywordAuthor | Microtubules | - |
dc.subject.keywordAuthor | KX-01 | - |
dc.subject.keywordAuthor | Triple negative breast neoplasms | - |
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