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Change in carbohydrate antigen 19-9 level as a prognostic marker of overall survival in locally advanced pancreatic cancer treated with concurrent chemoradiotherapy
DC Field | Value | Language |
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dc.contributor.author | Kim, Yi-Jun | - |
dc.contributor.author | Koh, Hyeon Kang | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Nam, Eun Mi | - |
dc.contributor.author | Kim, Kyubo | - |
dc.date.accessioned | 2021-01-31T11:53:47Z | - |
dc.date.available | 2021-01-31T11:53:47Z | - |
dc.date.created | 2018-07-25 | - |
dc.date.created | 2018-07-25 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | International Journal of Clinical Oncology, Vol.22 No.6, pp.1069-1075 | - |
dc.identifier.issn | 1341-9625 | - |
dc.identifier.other | 41164 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173114 | - |
dc.description.abstract | Purpose To investigate the significance of carbohydrate antigen 19-9 (CA19-9) levels for survival in locally advanced pancreatic cancer (LAPC) treated with concurrent chemoradiotherapy (CCRT). Methods/patients We retrospectively reviewed data from 97 LAPC patients treated with CCRT between 2000 and 2013. CA19-9 levels (initial and post-CCRT) and their changes [{(post-CCRT CA19-9 level - initial CA19-9 level)/(initial CA19-9 level)} x 100] were analyzed for overall survival. A cut-off point of 37 U/mL was used to analyze initial and post-CCRT CA19-9 levels. In order to define an optimal cut-off point for change in CA19-9 level, the maxstat package of R was applied. Results Median overall survival was 14.7 months (95% CI 13.4-16.0), and the 2-year survival rate was 16.5%. The estimated optimal cut-off point of CA19-9 level change was 94.4%. On univariate analyses, CA19-9 level change between initial and post-CCRT was significantly correlated with overall survival (median survival time 9.7 vs 16.3 months, p < 0.001). Multivariate analyses confirmed that CA19-9 level change from initial to post-CCRT was the only prognostic factor (p < 0.001). Conclusions Change in CA19-9 level between initial and post-CCRT was a significant prognostic marker for overall survival in LAPC treated with CCRT. A CA19-9 level increase > 94.4% might serve as a surrogate marker for poor survival in patients with LAPC undergoing CCRT, and the prognostic power surpassed other CA19-9 variables including initial and post-CCRT values. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Change in carbohydrate antigen 19-9 level as a prognostic marker of overall survival in locally advanced pancreatic cancer treated with concurrent chemoradiotherapy | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1007/s10147-017-1129-7 | - |
dc.citation.journaltitle | International Journal of Clinical Oncology | - |
dc.identifier.wosid | 000414780900011 | - |
dc.identifier.scopusid | 2-s2.0-85018770563 | - |
dc.citation.endpage | 1075 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 1069 | - |
dc.citation.volume | 22 | - |
dc.identifier.sci | 000414780900011 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NEOADJUVANT THERAPY | - |
dc.subject.keywordPlus | TUMOR-MARKERS | - |
dc.subject.keywordPlus | CA-19-9 | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | GEMCITABINE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CHEMORADIATION | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ELEVATION | - |
dc.subject.keywordAuthor | Locally advanced pancreatic cancer | - |
dc.subject.keywordAuthor | CA19-9 | - |
dc.subject.keywordAuthor | Concurrent chemoradiotherapy | - |
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