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A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells
DC Field | Value | Language |
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dc.contributor.author | Choi, Hyun Ho | - |
dc.contributor.author | Jong, Hyun-Soon | - |
dc.contributor.author | Park, Jung-Hyun | - |
dc.contributor.author | Choi, Seongwon | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Otsuki, Takemi | - |
dc.contributor.author | Namba, Masayoshi | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T11:53:58Z | - |
dc.date.available | 2021-01-31T11:53:58Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2003-10 | - |
dc.identifier.citation | International Journal of Oncology, Vol.23 No.4, pp.1087-1093 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.other | 4357 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173117 | - |
dc.description.abstract | Ginseng (the root of Panax ginseng C.A. Meyer, Araliaceae) has been used as a crude drug taken orally for preventive and therapeutic purposes in Asian countries as a traditional medicine. In the current study, we have investigated the antitumor effect of a novel ginseng protopanaxadiol saponin bacterial metabolic derivative, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (IH-901), in eight human myeloma cell lines. IH-901 inhibited the proliferation of all myeloma cell lines examined. Despite the fibroblast growth factor receptor 3 (FGFR3) overexpression due to a chromosomal translocation t(4;14)(q16.3;q32.3) in KMS-11 myeloma cells, IH-901 induced apoptosis in a dose- and time-dependent way in this cell line. Treatment of KMS-11 with IH-901 resulted in the formation of internucleosomal DNA fragments, poly (ADP-ribose) polymerase cleavage, and the activation of caspase-3. IH-901 also caused the down-regulation of FGFR3 mRNA and protein expression and inhibited ERK activity in KMS-11 cells. Our results demonstrate that IH-901 induces apoptosis and inhibits FGFR3 expression and signaling in KMS-11 cells, suggesting candidacy for the chemoprevention and the treatment of myeloma. | - |
dc.language | 영어 | - |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.3892/ijo.23.4.1087 | - |
dc.citation.journaltitle | International Journal of Oncology | - |
dc.identifier.wosid | 000185958100026 | - |
dc.identifier.scopusid | 2-s2.0-3042519041 | - |
dc.citation.endpage | 1093 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1087 | - |
dc.citation.volume | 23 | - |
dc.identifier.sci | 000185958100026 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Choi, Seongwon | - |
dc.contributor.affiliatedAuthor | Lee, Jung Weon | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | THANATOPHORIC DYSPLASIA | - |
dc.subject.keywordPlus | INTESTINAL BACTERIA | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | T(4-14)(P16.3-Q32) | - |
dc.subject.keywordPlus | ACHONDROPLASIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | ginseng saponin metabolite (IH-901) | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | fibroblast growth factor receptor 3 | - |
dc.subject.keywordAuthor | extracellular signal-regulated kinase | - |
dc.subject.keywordAuthor | myeloma cell lines | - |
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