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A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells

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dc.contributor.authorChoi, Hyun Ho-
dc.contributor.authorJong, Hyun-Soon-
dc.contributor.authorPark, Jung-Hyun-
dc.contributor.authorChoi, Seongwon-
dc.contributor.authorLee, Jung Weon-
dc.contributor.authorKim, Tae-You-
dc.contributor.authorOtsuki, Takemi-
dc.contributor.authorNamba, Masayoshi-
dc.contributor.authorBang, Yung-Jue-
dc.date.accessioned2021-01-31T11:53:58Z-
dc.date.available2021-01-31T11:53:58Z-
dc.date.issued2003-10-
dc.identifier.citationInternational Journal of Oncology, Vol.23 No.4, pp.1087-1093-
dc.identifier.issn1019-6439-
dc.identifier.other4357-
dc.identifier.urihttps://hdl.handle.net/10371/173117-
dc.description.abstractGinseng (the root of Panax ginseng C.A. Meyer, Araliaceae) has been used as a crude drug taken orally for preventive and therapeutic purposes in Asian countries as a traditional medicine. In the current study, we have investigated the antitumor effect of a novel ginseng protopanaxadiol saponin bacterial metabolic derivative, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol (IH-901), in eight human myeloma cell lines. IH-901 inhibited the proliferation of all myeloma cell lines examined. Despite the fibroblast growth factor receptor 3 (FGFR3) overexpression due to a chromosomal translocation t(4;14)(q16.3;q32.3) in KMS-11 myeloma cells, IH-901 induced apoptosis in a dose- and time-dependent way in this cell line. Treatment of KMS-11 with IH-901 resulted in the formation of internucleosomal DNA fragments, poly (ADP-ribose) polymerase cleavage, and the activation of caspase-3. IH-901 also caused the down-regulation of FGFR3 mRNA and protein expression and inhibited ERK activity in KMS-11 cells. Our results demonstrate that IH-901 induces apoptosis and inhibits FGFR3 expression and signaling in KMS-11 cells, suggesting candidacy for the chemoprevention and the treatment of myeloma.-
dc.subjectginseng saponin metabolite (IH-901)-
dc.subjectapoptosis-
dc.subjectfibroblast growth factor receptor 3-
dc.subjectextracellular signal-regulated kinase-
dc.subjectmyeloma cell lines-
dc.titleA novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.3892/ijo.23.4.1087-
dc.citation.journaltitleInternational Journal of Oncology-
dc.identifier.scopusid2-s2.0-3042519041-
dc.citation.endpage1093-
dc.citation.number4-
dc.citation.startpage1087-
dc.citation.volume23-
dc.identifier.urlhttps://www.spandidos-publications.com/10.3892/ijo.23.4.1087-
dc.identifier.rimsid4357-
dc.identifier.sci000185958100026-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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