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Real-World Treatment Patterns among Patients with Advanced Gastric Cancer in South Korea

Cited 8 time in Web of Science Cited 7 time in Scopus
Authors
Carter, Gebra Cuyun; Kaltenboeck, Anna; Ivanova, Jasmina; Liepa, Astra M.; Roman, Alexandra San; Koh, Maria; Rajan, Narayan; Cheng, Rebecca; Birnbaum, Howard G.; Kim, Jong Seok; Bang, Yung-Jue
Issue Date
2017-07
Citation
Cancer Research and Treatment, Vol.49 No.3, pp.578-587
Keywords
Treatment patternsStomach neoplasmsRepublic of KoreaResource useObservational study
Abstract
Purpose The purpose of this study was to understand patient treatment patterns, outcomes, and healthcare resource use in cases of metastatic and/or locally recurrent, unresectable gastric cancer (MGC) in South Korea. Materials and Methods Thirty physicians reviewed charts of eligible patients to collect de-identified data. Patients must have received platinum/fluoropyrimidine first-line therapy followed by second-line therapy or best supportive care, had no other primary cancer, and not participated in a clinical trial following MGC diagnosis. Data were summarized using descriptive statistics. Kaplan-Meier analysis was used to describe survival. Results Of 198 patients, 73.7% were male, 78.3% were diagnosed with MGC after age 55 (mean, 61.3 years), and 47.0% were current or former smokers. The majority of tumors were located in the antrum/pylorus (51.5%). Metastatic sites most often occurred in the peritoneum (53.5%), lymph nodes (47.5%), and liver (38.9%). At diagnosis, the mean Charlson comorbidity index was 0.4 (standard deviation, 0.6). The most common comorbidities were chronic gastritis (22.7%) and cardiovascular disease (18.7%). Most patients (80.3%) received second-line treatment. Single-agent fluoropyrimidine was reported for 22.0% of patients, while 19.5% were treated with irinotecan and a fluoropyrimidine or platinum agent. The most common physician-reported symptoms during second-line treatment were nausea/vomiting (44.7%) and pain (11.3%), with antiemetics (44.7%), analgesics (36.5%), and nutritional support (11.3%) most often used as supportive care. Two-thirds of inpatient hospitalizations were for chemotherapy infusion. Outpatient hospitalization (31.6%) and visits to the oncologist (58.8%) were common among second-line patients. Conclusion Most patients received second-line treatment, although regimens varied. Understanding MGC patient characteristics and treatment patterns in South Korea will help address unmet needs.
ISSN
1598-2998
URI
https://hdl.handle.net/10371/173134
DOI
https://doi.org/10.4143/crt.2016.001
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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