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CD99 regulates the transport of MHC class I molecules from the Golgi complex to the cell surface
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sohn, Hae Won | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Lee, Im-Soon | - |
dc.contributor.author | Bae, Young Mee | - |
dc.contributor.author | Suh, Young Ho | - |
dc.contributor.author | Kim, Min Kyung | - |
dc.contributor.author | Kim, Tae Jin | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.contributor.author | Park, Weon Seo | - |
dc.contributor.author | Park, Chan-Sik | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Ahn, Kwang Seog | - |
dc.contributor.author | Kim, In Sun | - |
dc.contributor.author | Ko, Young Hyeh | - |
dc.contributor.author | Bang, Yung Jue | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Park, Seong Hoe | - |
dc.date.accessioned | 2021-01-31T11:57:14Z | - |
dc.date.available | 2021-01-31T11:57:14Z | - |
dc.date.created | 2018-02-01 | - |
dc.date.issued | 2001-01 | - |
dc.identifier.citation | Journal of Immunology, Vol.166 No.2, pp.787-794 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 27940 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173157 | - |
dc.description.abstract | The down-regulation of surface expression of MHC class I molecules has recently been reported in the CD99-deficient lymphoblastoid B cell line displaying the characteristics of Hodgkin's and Reed-Sternberg phenotype. Here, we demonstrate that the reduction of MHC class I molecules on the cell surface is primarily due to a defect in the transport from the Golgi complex to the plasma membrane. Loss of CD99 did not affect the steady-state expression levels of mRNA and protein of MHC class I molecules. In addition, the assembly of MHC class I molecules and the transport from the endoplasmic reticulum to the cis-Golgi occurred normally in the CD99-deficient cells, and no difference was detected between the CD99-deficient and the control cells in the pattern and degree of endocytosis. Instead, the CD99-deficient cells displayed the delayed transport of newly synthesized MHC class I molecules to the plasma membrane, thus causing accumulation of the molecules within the cells. The accumulated MHC class I molecules in the CD99-deficient cells were colocalized with alpha -mannosidase II and gamma -adaptin in the Golgi compartment, These results suggest that CD99 may be associated with the post-Golgi trafficking machinery by regulating the transport to the plasma membrane rather than the endocytosis of surface MHC class I molecules, providing a novel mechanism of MHC class I downregulation for immune escape. | - |
dc.language | 영어 | - |
dc.publisher | American Association of Immunologists | - |
dc.title | CD99 regulates the transport of MHC class I molecules from the Golgi complex to the cell surface | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.4049/jimmunol.166.2.787 | - |
dc.citation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | 000166259600011 | - |
dc.identifier.scopusid | 2-s2.0-0035863806 | - |
dc.citation.endpage | 794 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 787 | - |
dc.citation.volume | 166 | - |
dc.identifier.sci | 000166259600011 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Shin, Young Kee | - |
dc.contributor.affiliatedAuthor | Bae, Young Mee | - |
dc.contributor.affiliatedAuthor | Suh, Young Ho | - |
dc.contributor.affiliatedAuthor | Chung, Doo Hyun | - |
dc.contributor.affiliatedAuthor | Ahn, Kwang Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung Jue | - |
dc.contributor.affiliatedAuthor | Kim, Chul Woo | - |
dc.contributor.affiliatedAuthor | Park, Seong Hoe | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MAJOR HISTOCOMPATIBILITY COMPLEX | - |
dc.subject.keywordPlus | ALPHA-MANNOSIDASE-II | - |
dc.subject.keywordPlus | REED-STERNBERG CELLS | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | PEPTIDE COMPLEXES | - |
dc.subject.keywordPlus | VESICLE FORMATION | - |
dc.subject.keywordPlus | COAT PROTEINS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NEF | - |
dc.subject.keywordPlus | PATHWAY | - |
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