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Bidirectional pharmacodynamic interaction between pegylated liposomal CKD-602 (S-CKD602) and monocytes in patients with refractory solid tumors

Cited 36 time in Web of Science Cited 37 time in Scopus
Authors
Zamboni, William C.; Maruca, Lauren J.; Strychor, Sandra; Zamboni, Beth A.; Ramalingam, Suresh; Edwards, Robert P.; Kim, J. K.; Bang, Yung-Jue; Lee, H. Y.; Friedland, David M.; Stoller, Ronald G.; Belani, Chandra P.; Ramanathan, Ramesh K.
Issue Date
2011-06
Citation
Journal of Liposome Research, Vol.21 No.2, pp.158-165
Keywords
S-CKD602STEALTH (R) liposomesmonocytespharmacokineticsclearance mechanisms
Abstract
Methods: aEuro,As part of a phase I study of S-CKD602 and phase I and II studies of NL-CKD602, the percent decreases in ANC and monocytes at their nadir were calculated. After S-CKD602, the amount of CKD-602 recovered in urine was measured. Results: aEuro,For S-CKD602 in patients < 60 years, the percent decrease in ANC and monocytes were 43 +/-+/- 31 and 58 +/-+/- 26%, respectively (P == 0.001). For S-CKD602 in patients >= a parts per thousand yen60, the percent decrease in ANC and monocytes were 41 +/-+/- 31 and 45 +/-+/- 36%, respectively (P == 0.50). For NL-CKD602 (n == 42), the percent decrease in ANC and monocytes were similar (P > 0.05). For S-CKD602, the relationship between the percent decrease in monocytes and CKD-602 recovered in urine was stronger in patients < 60 (R= a parts per thousand yen60 (R
ISSN
0898-2104
URI
https://hdl.handle.net/10371/173159
DOI
https://doi.org/10.3109/08982104.2010.496085
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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