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Prognostic implications of soluble programmed death-ligand 1 and its dynamics during chemotherapy in unresectable pancreatic cancer
DC Field | Value | Language |
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dc.contributor.author | Park, Hyunkyung | - |
dc.contributor.author | Bang, Ju-Hee | - |
dc.contributor.author | Nam, Ah-Rong | - |
dc.contributor.author | Park, Ji Eun | - |
dc.contributor.author | Jin, Mei Hua | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.date.accessioned | 2021-01-31T11:59:26Z | - |
dc.date.available | 2021-01-31T11:59:26Z | - |
dc.date.created | 2020-03-26 | - |
dc.date.created | 2020-03-26 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Scientific Reports, Vol.9 No.1, p. 11131 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | 93800 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173187 | - |
dc.description.abstract | In pancreatic cancer, acquiring a sufficient amount of tumor tissue is an obstacle. The soluble form of PD-L1 (sPD-L1) may have immunosuppressive activity. Here, we evaluated the prognostic implications of sPD-L1 in unresectable pancreatic cancer. We prospectively enrolled 60 patients treated with first-line FOLFIRINOX chemotherapy. We collected blood samples at diagnosis, first response assessment and disease progression. Serum sPD-L1 levels were measured using enzyme-linked immunosorbent assays. The median sPD-L1 level was 1.7 ng/mL (range, 0.4-5.7 ng/mL). Patients with low sPD-L1 level (<4.6 ng/mL) at diagnosis showed better overall survival (OS) than those with high sPD-L1 level (P= 0.015). Multivariate analysis identified sPD-L1 and the neutrophil-to-lymphocyte ratio as independent prognostic factors for OS. During chemotherapy, more patients achieved complete response (CR)/partia I response (PR) as their best response when sPD-L1 was decreased at the first response assessment (P = 0.038). In the patients who achieved CR/PR as their best response, sPD-L1 was significantly higher at the time of disease progression than at the first response assessment (P = 0.025). In conclusion, the sPD-L1 level at diagnosis exhibits a prognostic value in pancreatic cancer. Furthermore, sPD-L1 dynamics correlate with disease course and could be used to understand various changes in the tumor microenvironment during chemotherapy. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Prognostic implications of soluble programmed death-ligand 1 and its dynamics during chemotherapy in unresectable pancreatic cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1038/s41598-019-47330-1 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000477950800054 | - |
dc.identifier.scopusid | 2-s2.0-85069972677 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 11131 | - |
dc.citation.volume | 9 | - |
dc.identifier.sci | 000477950800054 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | ANTI-PD-L1 ANTIBODY | - |
dc.subject.keywordPlus | PEMBROLIZUMAB | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RECIST | - |
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