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Therapeutic implication of HER2 in advanced biliary tract cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Ah-Rong | - |
dc.contributor.author | Kim, Ji-Won | - |
dc.contributor.author | Cha, Yongjun | - |
dc.contributor.author | Ha, Hyerim | - |
dc.contributor.author | Park, Ji Eun | - |
dc.contributor.author | Bang, Ju-Hee | - |
dc.contributor.author | Jin, Mei Hua | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T12:02:44Z | - |
dc.date.available | 2021-01-31T12:02:44Z | - |
dc.date.created | 2018-09-10 | - |
dc.date.created | 2018-09-10 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | Oncotarget, Vol.7 No.36, pp.58007-58021 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.other | 52395 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173230 | - |
dc.description.abstract | Currently, there is no validated therapeutic target for biliary tract cancer (BTC). This study aimed to investigate the pre-clinical and clinical implication of HER2 as a therapeutic target in BTC. We established two novel HER2-amplified BTC cell lines, SNU-2670 and SNU-2773, from gallbladder cancer patients. SNU-2670 and SNU-2773 cells were sensitive to trastuzumab, dacomitinib, and afatinib compared with nine HER2-negative BTC cell lines. Dacomitinib and afatinib led to G1 cell cycle arrest in SNU-2773 cells and apoptosis in SNU-2670 cells. Furthermore, dacomitinib, afatinib, and trastuzumab showed synergistic cytotoxicity when combined with some cytotoxic drugs including gemcitabine, cisplatin, paclitaxel, and 5-fluorouracil. In a SNU-2670 mouse xenograft model, trastuzumab demonstrated a good anti-tumor effect as a monotherapy and in combination with gemcitabine increasing apoptosis. In our clinical data, 13.0% of patients with advanced BTC were defined as HER2-positive. Of these, three patients completed HER2-targeted chemotherapy. Two of them demonstrated a partial response, and the other one showed stable disease for 18 weeks. In summary, these pre-clinical and clinical data suggest that HER2 could be a therapeutic target, and that a HER2-targeting strategy should be developed further in patients with HER2-positive advanced BTC. | - |
dc.language | 영어 | - |
dc.publisher | Impact Journals | - |
dc.title | Therapeutic implication of HER2 in advanced biliary tract cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.18632/oncotarget.11157 | - |
dc.citation.journaltitle | Oncotarget | - |
dc.identifier.wosid | 000387153200044 | - |
dc.identifier.scopusid | 2-s2.0-84988370242 | - |
dc.citation.endpage | 58021 | - |
dc.citation.number | 36 | - |
dc.citation.startpage | 58007 | - |
dc.citation.volume | 7 | - |
dc.identifier.sci | 000387153200044 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROWTH-FACTOR-RECEPTOR | - |
dc.subject.keywordPlus | METASTATIC BREAST-CANCER | - |
dc.subject.keywordPlus | IN-SITU HYBRIDIZATION | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | EXTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | PROTEIN OVEREXPRESSION | - |
dc.subject.keywordPlus | GENE AMPLIFICATION | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordAuthor | HER2 | - |
dc.subject.keywordAuthor | biliary tract cancer | - |
dc.subject.keywordAuthor | gallbladder cancer | - |
dc.subject.keywordAuthor | trastuzumab | - |
dc.subject.keywordAuthor | targeted therapy | - |
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