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Impact of radiation dose in postoperative radiotherapy after R1 resection for extrahepatic bile duct cancer: long term results from a single institution
DC Field | Value | Language |
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dc.contributor.author | Kim, Byoung Hyuck | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Jang, Jin-Young | - |
dc.contributor.author | Kim, Sun Whe | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Ha, Sung W. | - |
dc.date.accessioned | 2021-01-31T12:02:56Z | - |
dc.date.available | 2021-01-31T12:02:56Z | - |
dc.date.created | 2018-09-18 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | Oncotarget, Vol.8 No.44, pp.78076-78085 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.other | 54577 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173233 | - |
dc.description.abstract | Purpose: This study was conducted to evaluate the impact of radiation dose after margin involved resection in patients with extrahepatic bile duct cancer. Methods: Among the 251 patients who underwent curative resection followed by adjuvant chemoradiotherapy, 86 patients had either invasive carcinoma (n = 63) or carcinoma in situ (n = 23) at the resected margin. Among them, 54 patients received conventional radiation dose (40-50.4 Gy) and 32 patients received escalated radiation dose (54-56 Gy). Results: Escalated radiation dose was associated with improved locoregional control (5yr rate, 73.8% vs. 47.1%, p = 0.069), but not disease-free survival (5yr rate, 43.4% vs. 32.6%, p = 0.490) and overall survival (5yr rate, 40.6% vs. 29.6%, p = 0.348). In multivariate analysis for locoregional control, invasive carcinoma at the margin (HR 2.957, p = 0.032) and escalated radiation dose (HR 0.394, p = 0.047) were independent prognostic factors. No additional gastrointestinal toxicity was observed in escalated dose group. Conclusions: Delivery of radiation dose = 54 Gy was well tolerated and associated with improved locoregional control, but not with overall survival after margin involved resection. Further validation study is warranted. | - |
dc.language | 영어 | - |
dc.publisher | Impact Journals | - |
dc.title | Impact of radiation dose in postoperative radiotherapy after R1 resection for extrahepatic bile duct cancer: long term results from a single institution | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.18632/oncotarget.17368 | - |
dc.citation.journaltitle | Oncotarget | - |
dc.identifier.wosid | 000412066700182 | - |
dc.identifier.scopusid | 2-s2.0-85030315119 | - |
dc.citation.endpage | 78085 | - |
dc.citation.number | 44 | - |
dc.citation.startpage | 78076 | - |
dc.citation.volume | 8 | - |
dc.identifier.sci | 000412066700182 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Jang, Jin-Young | - |
dc.contributor.affiliatedAuthor | Kim, Sun Whe | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Ha, Sung W. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BILIARY-TRACT CANCER | - |
dc.subject.keywordPlus | GEMCITABINE PLUS CISPLATIN | - |
dc.subject.keywordPlus | HILAR CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | LONGITUDINAL EXTENT | - |
dc.subject.keywordPlus | CURATIVE RESECTION | - |
dc.subject.keywordPlus | MARGIN STATUS | - |
dc.subject.keywordPlus | SPLIT-COURSE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CHEMORADIOTHERAPY | - |
dc.subject.keywordAuthor | extrahepatic bile duct cancer | - |
dc.subject.keywordAuthor | R1 resection | - |
dc.subject.keywordAuthor | postoperative radiotherapy | - |
dc.subject.keywordAuthor | radiation dose | - |
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