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Alteration of signal-transducing molecules and phenotypical characteristics in peripheral blood lymphocytes from gastric carcinoma patients

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dc.contributor.authorKim, CW-
dc.contributor.authorChoi, SH-
dc.contributor.authorChung, EJ-
dc.contributor.authorLee, MJ-
dc.contributor.authorByun, EK-
dc.contributor.authorRyu, MH-
dc.contributor.authorBang, Yung-Jue-
dc.date.accessioned2021-01-31T12:03:23Z-
dc.date.available2021-01-31T12:03:23Z-
dc.date.issued1999-05-
dc.identifier.citationPathobiology, Vol.67 No.3, pp.123-128-
dc.identifier.issn1015-2008-
dc.identifier.other119601-
dc.identifier.urihttps://hdl.handle.net/10371/173238-
dc.description.abstractThe mechanisms underlying the impaired immune response frequently observed in cancer patients are not fully understood. Alteration of T-cell-associated signal transduction molecules has recently been implicated in immune suppression in tumor-bearing hosts. Furthermore, T cells from tumor-bearing host, irrespective of the presence of the zeta-chain, showed a lack of proliferative activity and cytotoxic function. In the present study, we investigated the expression of the zeta-chain molecule and the p56(lck) and p59(fyn) protein tyrosine kinase (PTK) levels in peripheral blood T lymphocytes (T-PBL) from patients with advanced gastric carcinomas; for this, flow cytometric analysis and immunoblotting, respectively, were used. We also compared the results of flow cytometric analysis of PBL between stomach cancer patients and normal healthy volunteers. In T-PBL from 22 tumor-bearing hosts, significantly reduced zeta-chain expression (16/22, 73%) was observed. Moreover, the expression level of p56(lck) in T-PBL from patients was significantly lower than that of p59(fyn). Flow cytometric analysis of T-PBL indicated a markedly increased CD8+28- cell population in T-PBL from 19 tumor-bearing hosts.-
dc.subjectprotein tyrosine kinase-
dc.subjectimmune suppression-
dc.subjectstomach cancer-
dc.subjectCD8+28-T cells-
dc.titleAlteration of signal-transducing molecules and phenotypical characteristics in peripheral blood lymphocytes from gastric carcinoma patients-
dc.typeArticle-
dc.contributor.AlternativeAuthor방영주-
dc.identifier.doi10.1159/000028061-
dc.citation.journaltitlePathobiology-
dc.identifier.scopusid2-s2.0-0033011213-
dc.citation.endpage128-
dc.citation.number3-
dc.citation.startpage123-
dc.citation.volume67-
dc.identifier.urlhttps://www.karger.com/Article/Abstract/28061-
dc.identifier.rimsid119601-
dc.identifier.sci000081338100002-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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