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Clinical Implications of Cytotoxic T Lymphocyte Antigen-4 Expression on Tumor Cells and Tumor-Infiltrating Lymphocytes in Extrahepatic Bile Duct Cancer Patients Undergoing Surgery Plus Adjuvant Chemoradiotherapy
DC Field | Value | Language |
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dc.contributor.author | Lim, Yu Jin | - |
dc.contributor.author | Koh, Jaemoon | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Kim, Sehui | - |
dc.contributor.author | Lee, Kyoung Bun | - |
dc.contributor.author | Jang, Jin-Young | - |
dc.contributor.author | Kim, Sun Whe | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2021-01-31T12:04:57Z | - |
dc.date.available | 2021-01-31T12:04:57Z | - |
dc.date.created | 2018-09-05 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | Targeted Oncology, Vol.12 No.2, pp.211-218 | - |
dc.identifier.issn | 1776-2596 | - |
dc.identifier.other | 50746 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173260 | - |
dc.description.abstract | There currently is only limited knowledge on the role of tumor-specific immunity in cholangiocarcinoma. This study evaluated the clinical implications of cytotoxic T lymphocyte antigen-4 (CTLA-4) expression levels and CD4(+) and CD8(+) tumor-infiltrating lymphocytes (TILs) in extrahepatic bile duct (EHBD) cancer. Immunohistochemistry of CTLA-4, CD4, and CD8 was performed for 77 EHBD cancer patients undergoing surgery plus adjuvant chemoradiotherapy. CTLA-4 expression on tumor cells and TILs were assessed by using H-scores and the proportion of CTLA-4(+) lymphocytes, respectively. With optimal cutoff values determined by a maximal chi-square method with overall survival (OS) data, patients with CTLA-4 H-score > 70 and a proportion of CTLA-4(+) TILs > 0.15 showed higher mean density of CD8(+) and CD4(+) TILs, respectively (P = 0.025 for CD8(+) and P = 0.055 for CD4(+) TILs). The high CTLA-4 H-score level was associated with prolonged OS and disease-free interval (DFI) (P = 0.025 and 0.004, respectively). With differential levels of CTLA-4 H-score according to hilar and non-hilar locations (high rate 32 vs. 68%, respectively; P = 0.013), an exploratory subgroup analysis demonstrated that the associations between the CTLA-4 expression and OS and DFI were confined to hilar tumors (P = 0.003 and < 0.001, respectively), but not to non-hilar ones (P = 0.613 and 0.888, respectively). This study demonstrates a potential prognostic relevance of CTLA-4 expression in EHBD cancer. We suggest a differential survival impact of the CTLA-4 expression level according to different tumor locations. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Clinical Implications of Cytotoxic T Lymphocyte Antigen-4 Expression on Tumor Cells and Tumor-Infiltrating Lymphocytes in Extrahepatic Bile Duct Cancer Patients Undergoing Surgery Plus Adjuvant Chemoradiotherapy | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1007/s11523-016-0474-1 | - |
dc.citation.journaltitle | Targeted Oncology | - |
dc.identifier.wosid | 000398947800007 | - |
dc.identifier.scopusid | 2-s2.0-85010737611 | - |
dc.citation.endpage | 218 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 211 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000398947800007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Jang, Jin-Young | - |
dc.contributor.affiliatedAuthor | Kim, Sun Whe | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CTLA-4 | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | STATISTICS | - |
dc.subject.keywordPlus | BLOCKADE | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | STAGE | - |
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