Browse

The sequencing of chemotherapy and radiotherapy in breast cancer patients after mastectomy

Cited 0 time in Web of Science Cited 4 time in Scopus
Authors
Kim, Hak Jae; Kim, Jae-Sung; Chie, Eui Kyu; Noh, Dong-young; Bang, Yung-Jue; Ha, Sung Whan
Issue Date
2010-01
Citation
Tumori, Vol.96 No.1, pp.28-33
Keywords
breast cancerchemotherapyradiotherapysequence
Abstract
Background. The purpose of the study was to retrospectively evaluate the outcome according to the sequencing of radiotherapy and chemotherapy after mastectomy in high-risk patients with breast cancer. Methods. From January 1986 through September 2000, 275 women with stage I-IIIB breast cancer were treated with chemotherapy and radiotherapy after mastectomy The patients were divided into four groups. Chemotherapy was given first in 116 patients (CTRT), concurrent chemoradiotherapy in 77 (CCRT), sandwich therapy in 65 (SAND), and radiotherapy first in 17 (RTCT). Prognostic factors such as age, primary tumor size and nodal status were not statistically different among the four groups. There was a higher proportion of patients with close or positive margins in CCRT and RTCT groups than in the CTRT and SAND groups (22/77, 5/17 vs 3/116, 2/65, P<0.001). Results. Median follow-up was 145 months (range, 10-210). Five-year overall and disease-free survival were 69.4% and 56.1%, respectively Survival outcomes were not statistically different among the four groups (5-year overall/disease-free survival, 68.0%/63.0%, 71.3%/60.8%, 65.0%/48.1%, 81.9%/58.8%, in CTRT, CCRT, SAND, and RTCT, respectively) (P = 0.3422/P = 0.6333). The incidence of local-regional recurrence was not different in the early radiotherapy group (CCRT/RICT, 11%/12%) and delayed radiotherapy group (CTRT/SAND, 7%/8%). Conclusions. This study suggests that in these high-risk breast cancer patients after mastectomy, delay in the start of radiotherapy does not increase local-regional recurrence, and the final survival outcomes are not affected by the sequencing of chemotherapy and radiotherapy Free full text available at www.tumorionline.it
ISSN
0300-8916
URI
https://hdl.handle.net/10371/173272
DOI
https://doi.org/10.1700/479.5647
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse