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Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency

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Authors
Choi, Dong Il; Kim, Myeongwon; Kim, Somi; Yu, Nam-Kyung; Kwak, Chuljung; Seo, Hyunhyo; Lee, Kyungmin; Kaang, Bong-Kiun
Issue Date
2021-01-05
Publisher
BMC
Citation
Molecular Brain. 2021 Jan 05;14(1):1
Abstract
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits.
ISSN
1756-6606
Language
English
URI
https://hdl.handle.net/10371/173452
DOI
https://doi.org/10.1186/s13041-020-00716-z
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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