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Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Dong Il | - |
dc.contributor.author | Kim, Myeongwon | - |
dc.contributor.author | Kim, Somi | - |
dc.contributor.author | Yu, Nam-Kyung | - |
dc.contributor.author | Kwak, Chuljung | - |
dc.contributor.author | Seo, Hyunhyo | - |
dc.contributor.author | Lee, Kyungmin | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2021-03-08T05:23:17Z | - |
dc.date.available | 2021-03-08T15:17:47Z | - |
dc.date.issued | 2021-01-05 | - |
dc.identifier.citation | Molecular Brain. 2021 Jan 05;14(1):1 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173452 | - |
dc.description.abstract | CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits. | ko_KR |
dc.description.sponsorship | Supported by the National Research Foundation (NRF) through grants funded by the Korean government (MSIP) [NRF-2019R1F1A1063932] to K.L. and [NRF-2012R1A3A1050385] to B.K.K., and by LOreal Korea-UNESCO Women in Science fellowship and LOreal-UNESCO Rising Talent Award to N.K.Y. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.title | Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최동일 | - |
dc.contributor.AlternativeAuthor | 김명원 | - |
dc.contributor.AlternativeAuthor | 김소미 | - |
dc.contributor.AlternativeAuthor | 유남경 | - |
dc.contributor.AlternativeAuthor | 곽철중 | - |
dc.contributor.AlternativeAuthor | 서현효 | - |
dc.contributor.AlternativeAuthor | 이경민 | - |
dc.contributor.AlternativeAuthor | 강봉균 | - |
dc.identifier.doi | 10.1186/s13041-020-00716-z | - |
dc.citation.journaltitle | Molecular Brain | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-01-27T10:04:45Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 1 | ko_KR |
dc.citation.volume | 14 | ko_KR |
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