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Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses
DC Field | Value | Language |
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dc.contributor.author | Park, Pojeong | - |
dc.contributor.author | Kang, Heather | - |
dc.contributor.author | Georgiou, John | - |
dc.contributor.author | Zhuo, Min | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.contributor.author | Collingridge, Graham L | - |
dc.date.accessioned | 2021-05-10T05:47:26Z | - |
dc.date.available | 2021-05-10T15:00:40Z | - |
dc.date.issued | 2021-02-01 | - |
dc.identifier.citation | Molecular Brain. 2021 Feb 01;14(1):26 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174195 | - |
dc.description.abstract | The synaptic tag and capture (STC) hypothesis provides an important theoretical basis for understanding the synaptic basis of associative learning. We recently provided pharmacological evidence that calcium-permeable AMPA receptors (CP-AMPARs) are a crucial component of this form of heterosynaptic metaplasticity. Here we have investigated two predictions that arise on the basis of CP-AMPARs serving as a trigger of STC. Firstly, we compared the effects of the order in which we delivered a strong theta burst stimulation (TBS) protocol (75 pulses) and a weak TBS protocol (15 pulses) to two independent inputs. We only observed significant heterosynaptic metaplasticity when the strong TBS preceded the weak TBS. Second, we found that pausing stimulation following either the sTBS or the wTBS for ~20 min largely eliminates the heterosynaptic metaplasticity. These observations are consistent with a process that is triggered by the synaptic insertion of CP-AMPARs and provide a framework for establishing the underlying molecular mechanisms. | ko_KR |
dc.description.sponsorship | This work was supported by the CIHR (GLC), the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health, Canada Research Chair, and Cana‑dian Institute for Health Research operating Grants (CIHR66975 and 84256) (MZ) and the National Honor Scientist Program of the National Research Foundation funded by the South Korea Government (B-KK). This work was also supported by the Brain Canada Foundation through the Canada Brain Research Fund, with the fnancial support of Health Canada. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Synaptic tag and capture, Synapse specifcity | - |
dc.subject | Synaptic efcacy | - |
dc.subject | Synaptic potentiation | - |
dc.subject | Heterosynaptic plasticity | - |
dc.subject | Metaplasticity | - |
dc.subject | Learning | - |
dc.subject | Memory | - |
dc.title | Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박보정 | - |
dc.contributor.AlternativeAuthor | 강봉균 | - |
dc.identifier.doi | doi.org/10.1186/s13041-021-00737-2 | - |
dc.citation.journaltitle | Molecular Brain | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-02-15T10:30:36Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 26 | ko_KR |
dc.citation.volume | 14 | ko_KR |
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