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Non-association between low vitamin d levels and aeroallergen-positivity evaluated using multiple allergen simultaneous test in Korean adults
DC Field | Value | Language |
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dc.contributor.author | Wee, Jee Hye. | - |
dc.contributor.author | Cho, Sung Woo. | - |
dc.contributor.author | Kim, Jeong-Whun | - |
dc.contributor.author | Rhee, Chae-Seo | - |
dc.date.accessioned | 2021-05-14T02:21:59Z | - |
dc.date.available | 2021-05-14T11:23:53Z | - |
dc.date.issued | 2021-02-27 | - |
dc.identifier.citation | Allergy, Asthma & Clinical Immunology. 2021 Feb 27;17(1):23 | ko_KR |
dc.identifier.issn | 1710-1492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174365 | - |
dc.description.abstract | Background
Studies on the association between vitamin D levels and allergen sensitization have reported conflicting results. We aimed to evaluate the association between low vitamin D levels and sensitization to 59 aeroallergens in Korean adults. Methods We retrospectively reviewed serum 25-hydroxyvitamin D (25[OH]D) measurements of participants (n = 57,467) in a healthcare center between May 2003 and June 2020. Serum 25(OH)D levels were categorized as follows: severe deficiency (< 10ng/mL), deficiency (10 to < 20ng/mL), insufficiency (20 to < 30ng/mL), and sufficiency (≥ 30ng/mL). Among all subjects, 1277 simultaneously underwent the multiple allergen simultaneous test. Multiple linear and logistic regression analyses were used to estimate coefficients and odds ratios (ORs) with 95% confidence interval (CI) for the association between serum vitamin D deficiency and aeroallergen sensitization after adjustment for potential confounders. Subgroup analyses were conducted for the types of aeroallergen (house dust mites, pollens, animal dander, foods, cockroach, and fungus). Results Vitamin D deficiency, defined as serum 25(OH)D level < 20ng/mL, was noted in 56.4% of participants. There were significant differences in serum 25(OH)D levels according to sex, age, season, and bone mineral density (all P < 0.001). In multiple linear regression analyses, serum 25(OH)D levels were significantly lower in young subjects (adjusted coefficient [95% CI], 0.188 [0.101, 0.275]) and during winter (− 4.114 [− 6.528, − 1.699]). However, no significant association was observed between serum 25(OH)D levels and allergen sensitization (adjusted coefficients [95% CI], − 0.211 [− 1.989, 1.567], P = 0.816). In multivariate logistic regression analyses, male sex, young age, and winter season were significant risk factors for vitamin D deficiency. However, allergen sensitization showed no significant association with 25(OD)D levels after adjusting for confounders (adjusted OR [95% CI], 1.037 [0.642, 1.674] in insufficiency; 0.910 [0.573, 1.445] in deficiency; 0.869 [0.298, 2.539] in severe deficiency groups, P for trend = 0.334). There were consistent findings across subgroups regarding type of aeroallergen sensitized. Conclusion Vitamin D deficiency was prevalent but was not significantly associated with aeroallergen sensitization in Korean adults. To the best of our knowledge, this is the first large-scale study to evaluate the association between vitamin D deficiency and sensitization to 59 different aeroallergens. | ko_KR |
dc.description.sponsorship | This research was funded by National Research Foundation (NRF) of Korea, Grant Number (NRF-2020-R1G1A1005390 by Jee Hye Wee). The funding organization did not contribute to the design or conduct of this study, preparation, review, approval, or decision to submit this manuscript for publication. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Vitamin D | - |
dc.subject | Avitaminosis | - |
dc.subject | Allergy and immunology | - |
dc.subject | Population surveillance | - |
dc.subject | Health care surveys | - |
dc.title | Non-association between low vitamin d levels and aeroallergen-positivity evaluated using multiple allergen simultaneous test in Korean adults | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 위지혜 | - |
dc.contributor.AlternativeAuthor | 조성우 | - |
dc.contributor.AlternativeAuthor | 김정운 | - |
dc.contributor.AlternativeAuthor | 이채서 | - |
dc.identifier.doi | doi.org/10.1186/s13223-021-00525-6 | - |
dc.citation.journaltitle | Allergy, Asthma & Clinical Immunology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-02-28T04:21:46Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 23 | ko_KR |
dc.citation.volume | 17 | ko_KR |
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