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Oral probiotic activities and biosafety of Lactobacillus gasseri HHuMIN D

DC Field Value Language
dc.contributor.authorMann, Soyon-
dc.contributor.authorPark, Myeong Soo-
dc.contributor.authorJohnston, Tony V-
dc.contributor.authorJi, Geun Eog-
dc.contributor.authorHwang, Keum Taek-
dc.contributor.authorKu, Seockmo-
dc.date.accessioned2021-05-20T06:22:43Z-
dc.date.available2021-05-20T15:23:50Z-
dc.date.issued2021-03-23-
dc.identifier.citationMicrobial Cell Factories. 2021 Mar 23;20(1):75ko_KR
dc.identifier.issn1475-2859-
dc.identifier.urihttps://doi.org/10.1186/s12934-021-01563-w-
dc.identifier.urihttps://hdl.handle.net/10371/174435-
dc.description.abstractBackground
Lactobacillus spp. have been researched worldwide and are used in probiotics, but due to difficulties with laboratory cultivation of and experimentation on oral microorganisms, there are few reports of Lactobacillus spp. being isolated from the oral cavity and tested against oral pathogens. This research sought to isolate and determine the safety and inhibitory capabilities of a Lactobacillus culture taken from the human body.

Results
One organism was isolated, named L. gasseri HHuMIN D, and evaluated for safety. A 5% dilution of L. gasseri HHuMIN D culture supernatant exhibited 88.8% inhibition against halitosis-producing anaerobic microorganisms and the organism itself exhibited powerful inhibitory effects on the growth of 11 oral bacteria. Hydrogen peroxide production reached 802 μmol/L after 12 h and gradually diminished until 24 h, it efficiently aggregated with P. catoniae and S. sanguinis, and it completely suppressed S. mutans-manufactured artificial dental plaque. L. gasseri HHuMIN Ds KB cell adhesion capacity was 4.41 cells per cell, and the cell adhesion of F. nucleatum and S. mutans diminished strongly in protection and displacement assays.

Conclusion
These results suggest that L. gasseri HHuMIN D is a safe, bioactive, lactobacterial food ingredient, starter culture, and/or probiotic microorganism for human oral health.
ko_KR
dc.description.sponsorshipThis research was fnancially supported by the Gang-neung Science & Industry Promotion Agency (GSIPA), Korea, under the Regional development investment agreement pilot project. This work was also supported by a Faculty Research and Creative Activity Committee (FRCAC) grant (No. 221745) funded by Middle Tennessee State University in the U.S.ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectAntimicrobial Efect-
dc.subjectLactobacillus gasseri-
dc.subjectOral Microorganisms-
dc.subjectBiosafety Evaluation-
dc.titleOral probiotic activities and biosafety of Lactobacillus gasseri HHuMIN Dko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor맹소연-
dc.contributor.AlternativeAuthor박명수-
dc.contributor.AlternativeAuthor지근옥-
dc.contributor.AlternativeAuthor황금택-
dc.contributor.AlternativeAuthor구석모-
dc.citation.journaltitleMicrobial Cell Factoriesko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2021-03-28T03:09:26Z-
dc.citation.number1ko_KR
dc.citation.startpage75ko_KR
dc.citation.volume20ko_KR
Appears in Collections:
College of Human Ecology (생활과학대학)Dept. of Food and Nutrition (식품영양학과)Journal Papers (저널논문_식품영양학과)
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