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Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives

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Authors
Cho, Young-Dan; Kim, Woo-Jin; Ryoo, Hyun-Mo; Kim, Hong-Gee; Kim, Kyoung-Hwa; Ku, Young; Seol, Yang-Jo
Issue Date
2021-04-26
Publisher
BMC
Citation
Clinical Epigenetics. 2021 Apr 26;13(1):92
Keywords
Chronic diseaseEpigeneticsENCODE projectNext-generation sequencingPeriodontologyPersonalized medicine
Abstract
Background
The Encyclopedia of DNA Elements (ENCODE) project has advanced our knowledge of the functional elements in the genome and epigenome. The aim of this article was to provide the comprehension about current research trends from ENCODE project and establish the link between epigenetics and periodontal diseases based on epigenome studies and seek the future direction.

Main body
Global epigenome research projects have emphasized the importance of epigenetic research for understanding human health and disease, and current international consortia show an improved interest in the importance of oral health with systemic health. The epigenetic studies in dental field have been mainly conducted in periodontology and have focused on DNA methylation analysis. Advances in sequencing technology have broadened the target for epigenetic studies from specific genes to genome-wide analyses.

Conclusions
In line with global research trends, further extended and advanced epigenetic studies would provide crucial information for the realization of comprehensive dental medicine and expand the scope of ongoing large-scale research projects.
ISSN
1868-7083
Language
English
URI
https://hdl.handle.net/10371/174685
DOI
https://doi.org/10.1186/s13148-021-01074-w
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
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