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Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study

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dc.contributor.authorHan, Miyeun-
dc.contributor.authorKim, Hyunsuk-
dc.contributor.authorKim, Hyo Jin.-
dc.contributor.authorKang, Eunjeong-
dc.contributor.authorKim, Yong-Soo-
dc.contributor.authorChoi, Kyu Hun-
dc.contributor.authorKim, Soo Wan-
dc.contributor.authorAhn, Curie-
dc.contributor.authorOh, Kook-Hwan-
dc.date.accessioned2021-08-20T06:07:56Z-
dc.date.available2021-08-20T15:08:53Z-
dc.date.issued2021-07-04-
dc.identifier.citationBMC Nephrology. 2021 Jul 04;22(1):247ko_KR
dc.identifier.issn1471-2369-
dc.identifier.urihttps://hdl.handle.net/10371/174812-
dc.description.abstractBackground
Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort.

Methods
A total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC.

Results
CAC was detected in 705 (52.2 %) patients, and the level of UA was significantly higher in CAC > 0 patients. UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.04–1.19, P = 0.003). However, UA showed no association with CAC > 0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC > 0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m2 (OR 1.23, 95 % CI 1.02–1.49, P = 0.036) but not in eGFR 30–59 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.78–1.08, P = 0.309) or < 30 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.79–1.08, P = 0.426).

Conclusions
UA level was significantly associated with CAC in early CKD, but not in advanced CKD.
ko_KR
dc.description.sponsorshipThis study was supported by the Research Program funded by the Korea Center for Disease Control and Prevention (2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019E320101, and 2019E320102).ko_KR
dc.language.isoenko_KR
dc.publisherBMCko_KR
dc.subjectUric acid-
dc.subjectChronic kidney disease-
dc.subjectCoronary artery calcification-
dc.subjectCoronary computed tomography-
dc.titleSerum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor한미연-
dc.contributor.AlternativeAuthor김현석-
dc.contributor.AlternativeAuthor김효진-
dc.contributor.AlternativeAuthor강은정-
dc.contributor.AlternativeAuthor김용수-
dc.contributor.AlternativeAuthor최규훈-
dc.contributor.AlternativeAuthor김수완-
dc.contributor.AlternativeAuthor안규리-
dc.contributor.AlternativeAuthor오국환-
dc.identifier.doi10.1186/s12882-021-02463-2-
dc.citation.journaltitleBMC Nephrologyko_KR
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2021-07-11T03:17:34Z-
dc.citation.number1ko_KR
dc.citation.startpage247ko_KR
dc.citation.volume22ko_KR
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