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Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | Joo, Dong-Hyun | - |
dc.contributor.author | Lee, Kyoung-Hee | - |
dc.contributor.author | Lee, Chang-Hoon | - |
dc.contributor.author | Woo, Jisu | - |
dc.contributor.author | Kim, Jiyeon | - |
dc.contributor.author | Park, Seoung Ju | - |
dc.contributor.author | Rhee, Chin Kook | - |
dc.contributor.author | Lee, Won-Yeon | - |
dc.contributor.author | Park, Dongil | - |
dc.contributor.author | Lee, Jae Seung | - |
dc.contributor.author | Jung, Ki-Suck | - |
dc.contributor.author | Yoo, Kwang Ha | - |
dc.contributor.author | Yoo, Chul-Gyu | - |
dc.date.accessioned | 2022-03-02T01:53:15Z | - |
dc.date.available | 2022-03-02T10:54:36Z | - |
dc.date.issued | 2021-11-20 | - |
dc.identifier.citation | Respiratory Research. 2021 Nov 20;22(1):297 | ko_KR |
dc.identifier.issn | 1465-993X | - |
dc.identifier.uri | https://hdl.handle.net/10371/176996 | - |
dc.description.abstract | Background
Despite the high disease burden of chronic obstructive pulmonary disease (COPD) and risk of acute COPD exacerbation, few COPD biomarkers are available. As developmental endothelial locus-1 (DEL-1) has been proposed to possess beneficial effects, including anti-inflammatory effects, we hypothesized that DEL-1 could be a blood biomarker for COPD. Objective To elucidate the role of plasma DEL-1 as a biomarker of COPD in terms of pathogenesis and for predicting acute exacerbation. Methods Cigarette smoke extract (CSE) or saline was intratracheally administered to wild-type (WT) and DEL-1 knockout (KO) C57BL/6 mice. Subsequently, lung sections were obtained to quantify the degree of emphysema using the mean linear intercept (MLI). Additionally, plasma DEL-1 levels were compared between COPD and non-COPD participants recruited in ongoing prospective cohorts. Using negative binomial regression analysis, the association between the plasma DEL-1 level and subsequent acute exacerbation risk was evaluated in patients with COPD. Results In the in vivo study, DEL-1 KO induced emphysema (KO saline vs. WT saline; P = 0.003) and augmented CSE-induced emphysema (KO CSE vs. WT CSE; P < 0.001) in 29 mice. Among 537 participants, patients with COPD presented plasma log (DEL-1) levels lower than non-COPD participants (P = 0.04), especially non-COPD never smokers (P = 0.019). During 1.2 ± 0.3years, patients with COPD in the lowest quartile of Log(DEL-1) demonstrated an increased risk of subsequent acute exacerbation, compared with those in the highest quartile of Log(DEL-1) (adjusted incidence rate ratio, 3.64; 95% confidence interval, 1.03–12.9). Conclusion Low DEL-1 levels are associated with COPD development and increased risk of subsequent COPD acute exacerbation. DEL-1 can be a useful biomarker in patients with COPD. | ko_KR |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2019R1C1C1007918). This research was also supported by funds (2016ER670100, 2016ER670101, 2016ER670102 and 2018ER670100, 2018ER670101, 2018ER670102) from Research of Korea Centers for Disease Control and Prevention. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Chronic obstructive pulmonary disease | - |
dc.subject | Developmental endothelial locus-1 | - |
dc.subject | Disease progression | - |
dc.subject | Biomarkers | - |
dc.subject | Animal disease models | - |
dc.title | Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 주동현 | - |
dc.contributor.AlternativeAuthor | 이경희 | - |
dc.contributor.AlternativeAuthor | 이창훈 | - |
dc.contributor.AlternativeAuthor | 우지수 | - |
dc.contributor.AlternativeAuthor | 김지연 | - |
dc.contributor.AlternativeAuthor | 박성주 | - |
dc.contributor.AlternativeAuthor | 이진국 | - |
dc.contributor.AlternativeAuthor | 이원연 | - |
dc.contributor.AlternativeAuthor | 박동일 | - |
dc.contributor.AlternativeAuthor | 이재승 | - |
dc.contributor.AlternativeAuthor | 정기석 | - |
dc.contributor.AlternativeAuthor | 유광하 | - |
dc.contributor.AlternativeAuthor | 유철규 | - |
dc.identifier.doi | https://doi.org/10.1186/s12931-021-01878-7 | - |
dc.citation.journaltitle | Respiratory Research | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-11-21T04:21:37Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 297 | ko_KR |
dc.citation.volume | 22 | ko_KR |
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