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Graphene Quantum Dots Alleviate Impaired Functions in Niemann-Pick Disease Type C in Vivo

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dc.contributor.authorKang, Insung-
dc.contributor.authorYoo, Je Min-
dc.contributor.authorKim, Donghoon-
dc.contributor.authorKim, Juhee-
dc.contributor.authorCho, Myung Keun-
dc.contributor.authorLee, Seung-Eun-
dc.contributor.authorKim, Dong Jin-
dc.contributor.authorLee, Byung-Chul-
dc.contributor.authorLee, Jin Young-
dc.contributor.authorKim, Jae-Jun-
dc.contributor.authorShin, Nari-
dc.contributor.authorChoi, Soon Won-
dc.contributor.authorLee, Young-Ho-
dc.contributor.authorKo, Han Seok-
dc.contributor.authorShin, Seokmin-
dc.contributor.authorHong, Byung Hee-
dc.contributor.authorKang, Kyung-Sun-
dc.date.accessioned2022-04-18T04:11:53Z-
dc.date.available2022-04-18T04:11:53Z-
dc.date.issued2021-03-
dc.identifier.citationNano Letters, Vol.21 No.5, pp.2339-2346-
dc.identifier.issn1530-6984-
dc.identifier.other132750-
dc.identifier.urihttps://hdl.handle.net/10371/178080-
dc.description.abstractWhile the neuropathological characteristics of Niemann-Pick disease type C (NPC) result in a fatal diagnosis, the development of clinically available therapeutic agent remains a challenge. Here we propose graphene quantum dots (GQDs) as a potential candidate for the impaired functions in NPC in vivo. In addition to the previous findings that GQDs exhibit negligible long-term toxicity and are capable of penetrating the blood-brain barrier, GQD treatment reduces the aggregation of cholesterol in the lysosome through expressed physical interactions. GQDs also promote autophagy and restore defective autophagic flux, which, in turn, decreases the atypical accumulation of autophagic vacuoles. More importantly, the injection of GQDs inhibits the loss of Purkinje cells in the cerebellum while also demonstrating reduced activation of microglia. The ability of GQDs to alleviate impaired functions in NPC proves the promise and potential of the use of GQDs toward resolving NPC and other related disorders.-
dc.subjectgraphene quantum dots;nanomedicine;lysosomal storage disorders;Niemann-pick disease type C;cholesterol accumulation-
dc.titleGraphene Quantum Dots Alleviate Impaired Functions in Niemann-Pick Disease Type C in Vivo-
dc.typeArticle-
dc.contributor.AlternativeAuthor홍병희-
dc.contributor.AlternativeAuthor강경선-
dc.contributor.AlternativeAuthor신석민-
dc.identifier.doi10.1021/acs.nanolett.0c03741-
dc.citation.journaltitleNano Letters-
dc.identifier.scopusid2-s2.0-85100273502-
dc.citation.endpage2346-
dc.citation.number5-
dc.citation.startpage2339-
dc.citation.volume21-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acs.nanolett.0c03741-
dc.identifier.rimsid132750-
dc.identifier.sci000629091100058-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorHong, Byung Hee-
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