Publications
Detailed Information
Protein-Encoding Free-Standing RNA Hydrogel for Sub-Compartmentalized Translation
Cited 10 time in
Web of Science
Cited 11 time in Scopus
- Authors
- Issue Date
- 2022-05
- Citation
- Advanced Materials, Vol.34 No.18, p. 2110424
- Abstract
- RNA can self-fold into complex structures that can serve as major biological regulators in protein synthesis and in catalysis. Due to the abundance of structural primitives and functional diversity, RNA has been utilized for designing nature-defined goals despite its intrinsic chemical instability and lack of technologies. Here, a robust, free-standing RNA hydrogel is developed through a sequential process involving both ligation and rolling circle transcription to form RNA G-quadruplexes, capable of both catalytic activity and enhancing expression of several proteins in sub-compartmentalized, phase-separated translation environments. The observations suggest that this hydrogel will expand RNA research and impact practical RNA principles and applications.
- ISSN
- 0935-9648
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.