Publications
Detailed Information
Inflammatory myofibroblastic tumor of the central nervous system: clinicopathologic analysis of 10 cases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Chang, Kee-Hyun | - |
dc.contributor.author | Suh, Yeon-Lim | - |
dc.contributor.author | Jung, Hee Won | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.date.accessioned | 2009-12-03T08:32:28Z | - |
dc.date.available | 2009-12-03T08:32:28Z | - |
dc.date.issued | 2005-04-05 | - |
dc.identifier.citation | J Neuropathol Exp Neurol. 2005 Mar;64(3):254-9. | en |
dc.identifier.issn | 0022-3069 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15804057 | - |
dc.identifier.uri | https://hdl.handle.net/10371/18428 | - |
dc.description.abstract | To verify the pathologic features, anaplastic lymphoma kinase (ALK) expression and biologic behavior of inflammatory myofibroblastic tumors (IMTs) of the central nervous system (CNS), we analyzed 10 cases of IMTs-CNS (8 cranial, 1 spinal, and 1 orbital). Our series of IMTs of the CNS showed a male predominance (male:female = 6:4) and a wide age range (10-60 years; mean age, 46.7 years). Lesion location also varied, but they were basically dura-based. Radiologically, they showed two patterns: isolated mass forming (n = 6) and an en plaque-like pattern (n = 4). Histopathologically, plasma cell granuloma (PCG)-like (n = 5) or fibrohistiocytic (FHC) variant (n = 5) was present. No correlation was found between the radiologic and histopathologic patterns. Spindle-shaped mesenchymal cells of IMTs expressed smooth muscle actin (SMA) in all cases. ALK expression was not found in our IMTs of the CNS. Late recurrence was found in 2 cases in different sites (20%). Pathologically, IMT-CNS could be subclassified into PCG-like and FHC. Immunostaining for SMA was found to helpfully discriminate myofibroblastic cells and to make a differential diagnosis. Although our cases did not show ALK immunoreactivity, some IMTs-CNS can recur, which suggests the neoplastic potential of these tumors. The rearrangement of the ALK gene in IMTs-CNS should be verified by an examination of more cases. | en |
dc.language.iso | en | - |
dc.publisher | Lippincott, Williams & Wilkins | en |
dc.subject | Actins/metabolism | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Central Nervous System Neoplasms/metabolism/*pathology | en |
dc.subject | Female | en |
dc.subject | Granuloma, Plasma Cell/metabolism/pathology/physiopathology | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry/methods | en |
dc.subject | Inflammation/etiology/pathology | en |
dc.subject | Magnetic Resonance Imaging/methods | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasms, Muscle Tissue/*complications/metabolism/*pathology | en |
dc.subject | Sex Factors | en |
dc.subject | Staining and Labeling/methods | en |
dc.title | Inflammatory myofibroblastic tumor of the central nervous system: clinicopathologic analysis of 10 cases | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 장기현 | - |
dc.contributor.AlternativeAuthor | 서연림 | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
dc.contributor.AlternativeAuthor | 박성혜 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.