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Effects of leucine-rich protein supplements in older adults with sarcopenia: A systematic review and meta-analysis of randomized controlled trials

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Authors

Lee, Sang Yoon; Lee, Hyun Jeong; Lim, Jae-Young

Issue Date
2022-09
Publisher
Elsevier BV
Citation
Archives of Gerontology and Geriatrics, Vol.102, p. 104758
Abstract
© 2022 Elsevier B.V.Objectives: This study examined whether leucine-rich protein supplements improve muscle strength, mass, and performance in sarcopenic older adults. Methods: We searched PubMed-Medline, Embase, and Cochrane Library databases for randomized controlled trials comparing leucine-rich protein supplements with a control intervention in sarcopenic older adults. A pairwise meta-analysis using a fixed-effects model was performed. The primary outcome of interest was muscle strength regardless of the measures used. Effect sizes were computed as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Results: Six randomized controlled trials including a total of 699 participants were retrieved. Leucine-rich protein supplements improved participants overall muscle strength, mass, and performance compared to the control group (SMD = 0.939; 95% CI, 0.440–1.438; P < 0.001). As the primary outcome, muscle strength improved significantly in the leucine group (SMD = 0.794; 95% CI, 0.104–1.485; P = 0.024). Conclusion: Leucine-rich protein supplements improve muscle strength in sarcopenic older adults. They may be suggested in nutritional treatment of sarcopenia.
ISSN
0167-4943
URI
https://hdl.handle.net/10371/184573
DOI
https://doi.org/10.1016/j.archger.2022.104758
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