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Fiber Optic Plasmonic Sensors Based on Nanodome Arrays with Nanogaps

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Issue Date
2022-05
Publisher
AMER CHEMICAL SOC
Citation
Acs Sensors, Vol.7 No.5, pp.1451-1457
Abstract
In this study, a high-performancefiber optic surface plasmon resonance (FO-SPR) sensor using a dome array withnanogaps (DANG) is proposed for label-free real-time detection of biomolecules. A novel and simple method using polymer beadsenables high sensitivity by allowing hotspots with nanometer spacing between the Au dome and the surroundingfilm. Thenanodome structure, which comprises a polymer core and a Au shell, induces a localized surface plasmon, expands the sensing area,and extensively enhances the electromagneticfield. The refractive index sensitivity of the FO-SPR sensor with nanostructures, i.e.,with nanogaps and nanodomes, was found to be 7.8 times higher than that of the FO-SPR sensor without nanostructures. Theproposed sensor achieved a low detection limit of 38 fg/mL while quantifying thyroglobulin antibody-antigen interactions andexhibited excellent selectivity. In addition, it helped detect serum samples with a 103% recovery rate.
ISSN
2379-3694
URI
https://hdl.handle.net/10371/184930
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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