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Nonspecific protein labeling of photoaffinity linkers correlates with their molecular shapes in living cells
Cited 24 time in
Web of Science
Cited 24 time in Scopus
- Authors
- Issue Date
- 2016-04
- Publisher
- Royal Society of Chemistry
- Citation
- Chemical Communications, Vol.52 No.34, pp.5828-5831
- Abstract
- Herein we report molecular shape-dependent nonspecific labeling of photoaffinity linkers (PLs) in the cellular proteome. Linear PLs have a greater tendency to engage in nonspecific binding than branched PLs. Exploiting this property, we discovered a smaller branched diazirine-based PL as the best photoaffinity probe with minimal nonspecific binding characteristics from among 5 probes with different PLs.
- ISSN
- 1359-7345
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