Browse

Efficacy and safety of 1% and 2% rebamipide clear solution in dry eye disease: a multicenter randomized trial

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors

Eom, Youngsub; Chung, So Hyang; Chung, Tae-Young; Kim, Jae Young; Choi, Chul Young; Yoon, Kyung Chul; Ko, Byung Yi; Kim, Hong Kyun; Kim, Mee Kum; Lee, Hyung Keun; Song, Jong Suk; Hyon, Joon Young; Seo, Kyoung Yul; Lee, Jong Soo; Kim, Hyo Myung

Issue Date
2023-08-03
Citation
BMC Ophthalmology, Vol.23(1):343
Keywords
Dry Eye DiseaseQuinolonesCorneaTearsIntraocular pressure
Abstract
Background
To evaluate the efficacy of 1% and 2% rebamipide clear solution in the treatment of dry eye disease (DED).

Methods
Two hundred twenty patients with DED were randomly assigned to one of three groups: the 1% rebamipide, 2% rebamipide, or placebo (eye drops containing the same ingredients, except for the active components). Each eye drop was instilled four times daily for 12 weeks. Changes in tear film break-up time (TBUT), corneal and conjunctival staining score, Schirmer 1 test, and the Ocular Surface Disease Index (OSDI) from baseline to 12-week visit between the study groups were compared for efficacy assessment.

Results
The mean age of study patients was 43.8±14.2 years. The 1% and 2% rebamipide groups showed greater improvement in TBUT (1.99±1.87 and 2.02±2.21 s) at 12 weeks from baseline than the placebo group (1.25±2.93 s). The 2% rebamipide group showed greater improvement in the corneal staining score (− 3.15±2.00) at 12 weeks from baseline than the placebo group (− 2.85±1.80). The 1% and 2% rebamipide groups showed improvement in Schirmer 1 test (1.27±3.86 and 1.50±4.14 mm) at 12 weeks of treatment, but not the placebo group (0.55±2.99 mm). Both the rebamipide groups and the placebo group showed significantly improved OSDI after treatment for 12 weeks; however, there was no significant difference among the three groups.

Conclusions
1% and 2% rebamipide clear solutions are an effective therapeutic option for improving TBUT and tear volume, and stabilizing the corneal staining score in DED.
ISSN
1471-2415
Language
English
URI
https://hdl.handle.net/10371/195562
DOI
https://doi.org/10.1186/s12886-023-03004-1
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse