Detailed Information

Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice

Cited 31 time in Web of Science Cited 30 time in Scopus

Kwon, Bo-Eun; Song, Jae-Hyoung; Song, Hyuk-Hwan; Kang, Ju Won; Hwang, Sam Noh; Rhee, Ki-Jong; Shim, Aeri; Hong, Eun-Hye; Kim, Yeon-Jeong; Jeon, Sang-Min; Chang, Sun-Young; Kim, Dong-Eun; Cho, Sungchan; Ko, Hyun-Jeong

Issue Date
Public Library of Science
PLoS ONE, Vol.11 No.5, p. e0155784
The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intra-peritoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-alpha. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2 alpha in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Pharmacy
  • Department of Pharmacy
Research Area Cancer Origin, Metabolism, Toxicology


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.