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Evaluation of the benefit of radiotherapy in patients with occult breast cancer: A population-based analysis of the SEER database

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors

Kim, Byoung Hyuck; Kwon, Jeanny; Kim, Kyubo

Issue Date
2018-04
Publisher
대한암학회
Citation
Cancer Research and Treatment, Vol.50 No.2, pp.551-561
Abstract
Purpose Few studies for occult breast cancer (OBC) have evaluated the effect of radiotherapy (RT) after mastectomy or axillary lymph node dissection (ALND) with/without breast surgery. Therefore, we investigated clinicopathologic factors of OBC with the impact of postoperative RT to determine its prognostic significance using large population-based data. Materials and Methods We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2013. A total of 1,045 eligible patients with OBC were identified. We compared overall survival (OS) using Cox proportional hazards regression with propensity score matching after verifying an imbalance of prognosticators between RT group (n=518) and non-RT group (n=479). Results Patients with age < 70 (p=0.033), married marital status (p < 0.001), undergoing ALND (p < 0.001), more examined lymph nodes (LNs) (p < 0.001), and more metastatic LNs (p < 0.001) were more likely to receive RT. Multivariate analysis after propensity score matching (n=798) showed that patients treated with RT survived significantly longer than those without RT (5-year OS, 81.5% vs. 78.3%; p=0.014). A significantly prolonged OS was observed when RT was given to patients treated with mastectomy (p=0.033), those treated with ALND (p=0.036), or those with more than seven metastatic LNs (p=0.016). Conclusion RT may offer survival benefit in OBC even after mastectomy or ALND, especially in patients with more than seven metastatic LNs. Further prospective studies are needed to validate these findings.
ISSN
1598-2998
URI
https://hdl.handle.net/10371/201705
DOI
https://doi.org/10.4143/crt.2017.189
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Kim, Byoung hyuck김병혁
(기금)조교수
  • College of Medicine
  • Department of Medicine
Research Area 소화기암, 육종, 폐암

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