3D hierarchical scaffolds enabled by a post-patternable, reconfigurable, and biocompatible 2D vitrimer film for tissue engineering applications

Abstract

A mechanically tissue-like, biocompatible vitrimer film for tissue engineering scaffold applications is presented. 3D hierarchical scaffolds are prepared from the 2D vitrimer film via transesterificationinduced hot embossing patterning and additional reconfiguration processes. Microsized grooves patterned on the vitrimer surface are found to enhance C2C12 cell elongation and alignment for promoted muscle regeneration.