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Angiogenesis facilitated by autologous whole bone marrow stem cell transplantation for Buerger's disease

Cited 41 time in Web of Science Cited 55 time in Scopus
Authors

Kim, Dong-Ik; Kim, Mi-Jung; Joh, Jin-Hyun; Shin, Sung-Wook; Do, Young-Soo; Moon, Ji-Young; Kim, Na-Ri; Lim, Joung-Eun; Kim, Ae-Kyeong; Eo, Hyun-Seon; Kim, Byung-Soo; Cho, Seung-Woo; Yang, Seung-Hye; Park, Chan-Jeoung; Shim, Jong-Sup

Issue Date
2006-05
Publisher
AlphaMed Press Inc
Citation
Stem Cells, Vol.24 No.5, pp.1194-1200
Abstract
We hypothesized that angiogenesis can be triggered by antologous whole bone marrow stem cell transplantation. Twenty-seven patients (34 lower limbs) with Buerger's disease, who were not candidates for surgical revascularization or radiologic intervention, were enrolled in this study. Six sites of the tibia bone were fenestrated using a 2.5-mm-diameter screw under fluoroscopic guidance. Clinical status and outcome were determined using the "Recommended Standards for Reports." To mobilize endothelial progenitor cells (EPCs) from bone marrow, recombinant human granulocyte colony-stimulating factor (r-HuG-CSF) was injected subcutaneously as a dose of 75 mu g, preoperatively. During the follow-up period (19.1 +/- 3.5 months), one limb showed a markedly improved outcome (+3), and 26 limbs showed a moderately improved outcome (+2). Thirteen limbs among 17 limbs with nonhealing ulcers healed. Postoperative angiograms were obtained for 22 limbs. Two limbs showed marked (+3), five limbs moderate (+2), and nine limbs slight (+1) collateral development. However, six limbs showed no collateral development (0). Peripheral blood and bone marrow samples were analyzed for CD34 and CD133 molecules to enumerate potential EPCs, and EPC numbers were found to be increased in peripheral blood and in bone marrow after r-HuG-CSF injection. In conclusion, the transplantation of autologous whole BMCs by fenestration of the tibia bone represents a simple, safe, and effective means of inducing therapeutic angiogenesis in patients with Buerger's disease.
ISSN
1066-5099
URI
https://hdl.handle.net/10371/204412
DOI
https://doi.org/10.1634/stemcells.2005-0349
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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