Publications

Detailed Information

Post-treatment Radiographic Severity and Mortality in Mycobacterium avium Complex Pulmonary Disease

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors

Kim, Joong-Yub; Lee, Seowoo; Park, Hyungin; Kim, Hyung-Jun; Lee, Hyun Woo; Lee, Jae Ho; Yim, Jae-Joon; Kwak, Nakwon; Yoon, Soon Ho

Issue Date
2024-02
Publisher
American Thoracic Society
Citation
Annals of the American Thoracic Society, Vol.21 No.2, pp.235-242
Abstract
Rationale: Imaging studies are widely performed when treating Mycobacterium avium complex pulmonary disease (MAC-PD); however, the clinical significance of post-treatment radiographic change is unknown. Objectives: To determine whether a deep neural network trained with pulmonary tuberculosis could adequately score the radiographic severity of MAC-PD and then to examine relationships between post-treatment radiographic severity and its change from baseline and long-term prognosis. Methods: We retrospectively collected chest radiographs of adult patients with MAC-PD treated for ⩾6 months at baseline and at 3, 6, 9, and 12 months of treatment. We correlated the radiographic severity score generated by a deep neural network with visual and clinical severity as determined by radiologists and mycobacterial culture status, respectively. The associations between the score, improvement from baseline, and mortality were analyzed using Cox proportional hazards regression. Results: In total, 342 and 120 patients were included in the derivation and validation cohorts, respectively. The network's severity score correlated with radiologists' grading (Spearman coefficient, 0.40) and mycobacterial culture results (odds ratio, 1.02; 95% confidence interval [CI], 1.0-1.05). A significant decreasing trend in the severity score was observed over time (P < 0.001). A higher score at 12 months of treatment was independently associated with higher mortality (adjusted hazard ratio, 1.07; 95% CI, 1.03-1.10). Improvements in radiographic scores from baseline were associated with reduced mortality, regardless of culture conversion (adjusted hazard ratio, 0.42; 95% CI, 0.22-0.80). These findings were replicated in the validation cohort. Conclusions: Post-treatment radiographic severity and improvement from baseline in patients with MAC-PD were associated with long-term survival.
ISSN
2329-6933
URI
https://hdl.handle.net/10371/205123
DOI
https://doi.org/10.1513/AnnalsATS.202305-407OC
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Medicine
  • Department of Medicine
Research Area Nontuberculous Mycobacteria, Tuberculosis, multidrug-resistant tuberculosis, 결핵, 다제내성결핵, 비결핵항산균 폐질환

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share