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Phenalenones from a marine-derived fungus Penicillium sp.

DC Field Value Language
dc.contributor.authorPark, Sung Chul-
dc.contributor.authorJulianti, Elin-
dc.contributor.authorAhn, Sungjin-
dc.contributor.authorKim, Donghwa-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorNoh, Minsoo-
dc.contributor.authorOh, Dong-Chan-
dc.contributor.authorOh, Ki-Bong-
dc.contributor.authorShin, Jongheon-
dc.date.accessioned2024-08-08T01:30:05Z-
dc.date.available2024-08-08T01:30:05Z-
dc.date.created2019-10-24-
dc.date.created2019-10-24-
dc.date.issued2019-03-
dc.identifier.citationMarine Drugs, Vol.17 No.3, p. 176-
dc.identifier.issn1660-3397-
dc.identifier.urihttps://hdl.handle.net/10371/206296-
dc.description.abstractSix new phenalenone derivatives (1-6), along with five known compounds (7-11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.-
dc.language영어-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.titlePhenalenones from a marine-derived fungus Penicillium sp.-
dc.typeArticle-
dc.identifier.doi10.3390/md17030176-
dc.citation.journaltitleMarine Drugs-
dc.identifier.wosid000466398200040-
dc.identifier.scopusid2-s2.0-85063251912-
dc.citation.number3-
dc.citation.startpage176-
dc.citation.volume17-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorLee, Sang Kook-
dc.contributor.affiliatedAuthorNoh, Minsoo-
dc.contributor.affiliatedAuthorOh, Dong-Chan-
dc.contributor.affiliatedAuthorOh, Ki-Bong-
dc.contributor.affiliatedAuthorShin, Jongheon-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSCLERODERRIS CANKER FUNGUS-
dc.subject.keywordPlusHERQUEINONE-
dc.subject.keywordPlusMETABOLITES-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusATROVENETIN-
dc.subject.keywordPlusACETYLATION-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusALCOHOLS-
dc.subject.keywordPlusPHENOLS-
dc.subject.keywordAuthorherqueinones-
dc.subject.keywordAuthorphenalenones-
dc.subject.keywordAuthorPenicillium sp-
dc.subject.keywordAuthormarine-derived fungi-
dc.subject.keywordAuthoradipogenesis-
dc.subject.keywordAuthoranti-angiogenesis-
dc.subject.keywordAuthoranti-inflammatory-
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Chemical biology of natural products, Drug discovery from microbial natural products, Study of insect-microbial symbiosis, 미생물 유래 생리활성 천연물 발굴, 천연물 구조 분석

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