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DNA topoisomerase inhibitory activity of constituents from the fruits of illicium verum
Cited 3 time in
Web of Science
Cited 3 time in Scopus
- Authors
- Issue Date
- 2017-12
- Publisher
- Pharmaceutical Society of Japan
- Citation
- Chemical and Pharmaceutical Bulletin, Vol.65 No.12, pp.1179-1184
- Abstract
- Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4-10), were isolated from the fruits of Illicium verum Hook. FIL. (Illiciaceae). The structures of 1-3 were determined based on one and two dimensional (ID- and 2D-) NMR data and electronic circular dichroism (ECD) spectra analyses. Compounds 3, 5, 6, and 8-10 exhibited potent inhibitory activities against topoisomerase 11 with IC50 values of 54.6, 25.5, 17.9, 12.1, 0.3 and 1.0 mu m, respectively, compared to etoposide, the positive control, with an IC50 of 43.8 mu m.
- ISSN
- 0009-2363
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