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DNA topoisomerase inhibitory activity of constituents from the fruits of illicium verum

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors

Kim, Tae In; Shin, Bora; Kim, Geum Jin; Choi, Hyukjae; Lee, Chong Soon; Woo, Mi Hee; Oh, Dong-Chan; Son, Jong Keun

Issue Date
2017-12
Publisher
Pharmaceutical Society of Japan
Citation
Chemical and Pharmaceutical Bulletin, Vol.65 No.12, pp.1179-1184
Abstract
Three new compounds, a sesquilignan (1) and two glucosylated phenylpropanoids (2, 3), and seven known compounds (4-10), were isolated from the fruits of Illicium verum Hook. FIL. (Illiciaceae). The structures of 1-3 were determined based on one and two dimensional (ID- and 2D-) NMR data and electronic circular dichroism (ECD) spectra analyses. Compounds 3, 5, 6, and 8-10 exhibited potent inhibitory activities against topoisomerase 11 with IC50 values of 54.6, 25.5, 17.9, 12.1, 0.3 and 1.0 mu m, respectively, compared to etoposide, the positive control, with an IC50 of 43.8 mu m.
ISSN
0009-2363
URI
https://hdl.handle.net/10371/206608
DOI
https://doi.org/10.1248/cpb.c17-00466
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Chemical biology of natural products, Drug discovery from microbial natural products, Study of insect-microbial symbiosis, 미생물 유래 생리활성 천연물 발굴, 천연물 구조 분석

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