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Effect of tiotropium on lung function decline in early-stage of chronic obstructive pulmonary disease patients: propensity score-matched analysis of real-world data

Cited 5 time in Web of Science Cited 5 time in Scopus
Authors

Lee, Ha Youn; Choi, Sun Mi; Lee, Jinwoo; Park, Young Sik; Lee, Chang-Hoon; Kim, Deog Kyeom; Lee, Sang-Min; Yoon, Ho Il; Yim, Jae-Joon; Kim, Young Whan; Han, Sung Koo; Yoo, Chul-Gyu

Issue Date
2015-10
Publisher
Dove Medical Press Ltd
Citation
International Journal of COPD, Vol.10 No.1, pp.2185-2192
Abstract
Background: Tiotropium failed to slow the annual rate of forced expiratory volume in 1 second (FEV1) decline in chronic obstructive pulmonary disease (COPD) patients with,70% predicted FEV1. However, the rate of FEV1 decline is known to be faster at early stages, which suggests that the effects of tiotropium may be more prominent in early-stage of COPD patients. The aim of this study was to test the hypothesis that tiotropium modifies the rate of FEV1 decline in COPD patients with an FEV1 >= 70%. Methods: We retrospectively reviewed the records of COPD patients diagnosed between January 1, 2004, and July 31, 2012, at Seoul National University Hospital, Seoul National University Bundang Hospital, and Seoul Metropolitan Government-Seoul National University Boramae Medical Center. The inclusion criteria were as follows: age >= 40 years, postbronchodilator (BD) FEV1 >= 70% of predicted and FEV1/FVC (forced vital capacity) <0.70, and spirometry more than two times at certain times of the year. Conversely, the exclusion criteria were as follows: asthma, lung cancer, pulmonary tuberculosis, pulmonary resection, or longterm use of a short-acting muscarinic antagonist. The annual lung function decline in patients using tiotropium was compared with that in patients not using the drug. Results: Of the 587 patients enrolled in the study, 257 took tiotropium. Following propensity score matching, 404 patients were included in the analysis. The mean annual rate of post-BD FEV1 decline was 23.9 (tiotropium) and 22.5 (control) mL/yr (P=0.86); corresponding pre-BD values were 30.4 and 21.9 mL/yr (P=0.31), respectively. Mean annual rate of post-BD FVC decline was 55.1 (tiotropium) and 43.5 (control) mL/yr (P=0.33); corresponding pre-BD values were 37.1 and 33.3 mL/yr (P=0.13). Conclusion: Therefore, tiotropium does not reduce the rate of lung function decline in COPD patients with FEV1 >= 70%.
ISSN
1176-9106
URI
https://hdl.handle.net/10371/207117
DOI
https://doi.org/10.2147/COPD.S91901
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  • College of Medicine
  • Department of Medicine
Research Area Nontuberculous Mycobacteria, Tuberculosis, multidrug-resistant tuberculosis, 결핵, 다제내성결핵, 비결핵항산균 폐질환

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