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Coprisamides A and B, New Branched Cyclic Peptides from a Gut Bacterium of the Dung Beetle Copris tripartitus

DC Field Value Language
dc.contributor.authorUm, Soohyun-
dc.contributor.authorPark, So Hyun-
dc.contributor.authorKim, Jihye-
dc.contributor.authorPark, Hyen Joo-
dc.contributor.authorKo, Keebeom-
dc.contributor.authorBang, Hea-Son-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorShin, Jongheon-
dc.contributor.authorOh, Dong-Chan-
dc.date.accessioned2024-08-08T01:40:53Z-
dc.date.available2024-08-08T01:40:53Z-
dc.date.created2017-11-15-
dc.date.created2017-11-15-
dc.date.issued2015-03-
dc.identifier.citationOrganic Letters, Vol.17 No.5, pp.1272-1275-
dc.identifier.issn1523-7060-
dc.identifier.urihttps://hdl.handle.net/10371/207277-
dc.description.abstractCoprisamides A and B (1 and 2) were isolated from a bacterium in the gut of the dung beetle Copris tripartitus. Spectroscopic analysis revealed that the planar structures of 1 and 2 are novel cyclic heptapeptides bearing unusual units, such as beta-methylaspartic acid and 2,3-diaminopropanoic acid branched to valine and 2-heptatrienyl cinnamic acid. Absolute configurations were established by chemical derivatization and chiroptical spectroscopy. The coprisamides displayed significant activity for induction of quinone reductase.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleCoprisamides A and B, New Branched Cyclic Peptides from a Gut Bacterium of the Dung Beetle Copris tripartitus-
dc.typeArticle-
dc.identifier.doi10.1021/acs.orglett.5b00249-
dc.citation.journaltitleOrganic Letters-
dc.identifier.wosid000350841300054-
dc.identifier.scopusid2-s2.0-84929223336-
dc.citation.endpage1275-
dc.citation.number5-
dc.citation.startpage1272-
dc.citation.volume17-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorLee, Sang Kook-
dc.contributor.affiliatedAuthorShin, Jongheon-
dc.contributor.affiliatedAuthorOh, Dong-Chan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusABSOLUTE-CONFIGURATION-
dc.subject.keywordPlusSTREPTOMYCES-
dc.subject.keywordPlusDIVERSITY-
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Chemical biology of natural products, Drug discovery from microbial natural products, Study of insect-microbial symbiosis, 미생물 유래 생리활성 천연물 발굴, 천연물 구조 분석

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