악골골수염 처치를 위한 조직공학적 접근

Abstract

Osteomyelitis is truly an infection of bone, and osteomyelitis of the jaws is defined as an inflammatory process of the medullary portion of the affected bone and eventually extends to include the haversian systems and the periosteum. Osteomyelitis of the jaws is caused primarily by contiguous spread of odontogenic infections originating from pulpal or periodontal tissues, and infections derived from trauma, especially compound fractures, are the second leading cause, and from the periostitis after gingival ulceration, infected lymph nodes or hematogenous origin account for an additional causes of jaw infections. Despite all recent advances in diagnosis and treatment modalities, such as surgical intervention, antibiotic, and hyperbaric oxygen treatment, for osteomyelitis of the jaws are well established, osteomyelitis of the jaws is still a very unique and difficult disease leading to uncertain outcomes with many complications involving facial disfigurement, loss of jaw functions by loss of affected bone, teeth, and nerve. Understanding of the pathophysiology and microbiology of the osteomyelitis is important to selection of adequate treatment, it is thought that the recent rapid progress in the research fields of tissue-engineered bone and antibiotic delivery systems should be adjusted and modified to the biological nature will be applicated to solve the minimal invasive treatment of osteomyelitis of the jaws. Therefore, the present study authors reviewed about pathophysiology and microbiology of osteomyelitis of the jaws, and recent trends of tissue engineering approaches, so intended to inform to clinicians and researchers about whole entities of this disease.