Biological functions of a synthetic compound, octadeca-9,12-dienyl-3,4,5-hydroxybenzoate, from gallic acid-linoleic acid ester

Abstract

Octadeca-9,12-dienyl-3,4,5-hydroxybenzoate (GA-LA) was synthesized chemically from gallic acid and linoleic acid ester and its biological function was investigated for further application purpose. This newly synthesized compound GA-LA possesses a strong and synergistic effect on cancer cell proliferation inhibition; however, no synergistic effect was found for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP), and inhibition effect against xanthine oxidase, hyaluronidase, and tyrosinase. Nevertheless, synthetic GA-LA possessed comparable biological activities when compared with gallic acid and tocopherol. With anti-mutagenic activity it can be concluded that this compound may be a useful functional material for the food, pharmaceutical, and cosmetic industry. (C) 2008 Elsevier Ltd. All rights reserved.