Benzoyl Peroxide의 반복투여 독성과 생식 및 발생독성

Abstract

This study was carried out to assess the combined repeated dose, reproduction anddevelopmental toxicities of benzoyl peroxide for OECD SIDS (Screening Information Data Set) pro-gram. Male and female Sprague-Dawley rats were exposed to benzoyl peroxide at dose levels of 0,250, 500 and 1,000 mg/kg/day for 29 days for males and for 41~51 days for females. No deaths werefound in all animals including control group during exposure period. No hematological effects attribut-able to benzoyl peroxide were observed in all treated groups. Significant decrease in the weight oftestes and epididymis were observed in males at 1,000 mg/kg/day. In females at 1,000 mg/kg/day,slight histopathological effects in uterus such as epithelial vacuolation or hyperplasia were observed.No treatment-related changes in precoital time and rate of copulation, fertility and gestation periodwere noted in all treated groups. There was no evidence of teratogenic effect of benzoyl peroxide, butbody weight of pups at 1,000 mg/kg/day was significantly decreased. NOAEL for combined repeateddose and reproduction/developmental toxicity was 500 mg/kg/day.