랫드에서 방풍, Saposhnikovia divaricata ( Turcz.) Schischk의 피하투여 독성에 대한 연구

Abstract

To evaluate influence of Saposhnikovia divaricata (Turcz.) Schischk extract on rat,Saposhnikovia divaricata (Turcz.) Schischk extract was diluted with 0.9% saline (100 mg/ml/kg,10 mg/ml/kg, and 1 mg/ml/kg, respectively), and each of diluted test material extract was daily treatedsubcutaneously for 4 weeks and single-treated subcutaneously for 2 weeks. There were no significan-ces in body weight analysis, urinary analysis, and ophthalmological test. However, in serum biochemi-cal analysis and hematological analysis, we found some significances in high and middle dose groupcompared with control group. These significances in serum biochemical analysis and hematologicalanalysis may be not induced by test material, because it was not found to be significant from controlgroup in histopathological examination. Therefore, it was concluded that NOEL (No Observed EffectLevel) of test material extract may be higher than all treatment doses used in this study, and Saposh-nikovia divaricata (Turcz.) Schischk extract may be a non-toxic material.