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Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baik, Seungmin | - |
dc.contributor.author | Kim, Hyunmin | - |
dc.contributor.author | Lee, Yunjung | - |
dc.contributor.author | Kang, Taegyu | - |
dc.contributor.author | Shin, Kwangsoo | - |
dc.contributor.author | Song, Changyeong | - |
dc.contributor.author | Park, Ok Kyu | - |
dc.contributor.author | Kang, Byeonggeun | - |
dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Kim, Seung Han | - |
dc.contributor.author | Soh, Min | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Kim, Chi Kyung | - |
dc.date.accessioned | 2024-12-11T06:04:29Z | - |
dc.date.available | 2024-12-11T06:04:29Z | - |
dc.date.created | 2024-12-11 | - |
dc.date.issued | 2024-09 | - |
dc.identifier.citation | Advanced Healthcare Materials, p. 2401994 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | https://hdl.handle.net/10371/213564 | - |
dc.description.abstract | Ceria-based nanoparticles are versatile in treating various inflammatory diseases, but their feasibility in clinical translation is undermined by safety concerns and a limited delivery system. Meanwhile, the idiopathic nature of inflammatory bowel disease (IBD) calls for a wider variety of therapeutics via moderation of the intestinal immune system. In this regard, the synthesis and oral formulation of iron-ceria nanoparticles (CF NPs) with enhanced nanozymic activity and lower toxicity risk than conventional ceria-based nanoparticles are reported. CF NPs are clustered in calcium phosphate (CaP) and coated with a pH-responsive polymer to provide the enteric formulation of iron-ceria nanotablets (CFNT). CFNT exhibits a marked alleviative efficacy in the dextran sodium sulfate (DSS)-induced enterocolitis model in vivo by modulating the pro-inflammatory behavior of innate immune cells including macrophages and neutrophils, promoting anti-inflammatory cytokine profiles, and downregulating key transcription factors of inflammatory pathways. For enteric delivery of ceria-based anti-inflammatory nanozymes, iron-ceria nanoparticles with lower toxicity and higher catalytic activity are formulated into iron-ceria nanotablets (CFNT). Orally administered CFNT provides therapeutic efficacy on the enterocolitis model in vivo by manipulating the behavior of immune cells, cytokine secretion, and transcription factors toward an anti-inflammatory environment. image | - |
dc.language | 영어 | - |
dc.publisher | Wiley-Blackwell | - |
dc.title | Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adhm.202401994 | - |
dc.citation.journaltitle | Advanced Healthcare Materials | - |
dc.identifier.wosid | 001306136900001 | - |
dc.identifier.scopusid | 2-s2.0-85203087618 | - |
dc.citation.startpage | 2401994 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | OXIDE | - |
dc.subject.keywordPlus | ADSORPTION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordAuthor | anti-inflammations | - |
dc.subject.keywordAuthor | enteric delivery | - |
dc.subject.keywordAuthor | inflammatory bowel diseases | - |
dc.subject.keywordAuthor | iron-ceria nanoparticles | - |
dc.subject.keywordAuthor | nanomedicines | - |
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