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Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease

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dc.contributor.authorBaik, Seungmin-
dc.contributor.authorKim, Hyunmin-
dc.contributor.authorLee, Yunjung-
dc.contributor.authorKang, Taegyu-
dc.contributor.authorShin, Kwangsoo-
dc.contributor.authorSong, Changyeong-
dc.contributor.authorPark, Ok Kyu-
dc.contributor.authorKang, Byeonggeun-
dc.contributor.authorLee, Nohyun-
dc.contributor.authorKim, Dokyoon-
dc.contributor.authorChoi, Seung Hong-
dc.contributor.authorKim, Seung Han-
dc.contributor.authorSoh, Min-
dc.contributor.authorHyeon, Taeghwan-
dc.contributor.authorKim, Chi Kyung-
dc.date.accessioned2024-12-11T06:04:29Z-
dc.date.available2024-12-11T06:04:29Z-
dc.date.created2024-12-11-
dc.date.issued2024-09-
dc.identifier.citationAdvanced Healthcare Materials, p. 2401994-
dc.identifier.issn2192-2640-
dc.identifier.urihttps://hdl.handle.net/10371/213564-
dc.description.abstractCeria-based nanoparticles are versatile in treating various inflammatory diseases, but their feasibility in clinical translation is undermined by safety concerns and a limited delivery system. Meanwhile, the idiopathic nature of inflammatory bowel disease (IBD) calls for a wider variety of therapeutics via moderation of the intestinal immune system. In this regard, the synthesis and oral formulation of iron-ceria nanoparticles (CF NPs) with enhanced nanozymic activity and lower toxicity risk than conventional ceria-based nanoparticles are reported. CF NPs are clustered in calcium phosphate (CaP) and coated with a pH-responsive polymer to provide the enteric formulation of iron-ceria nanotablets (CFNT). CFNT exhibits a marked alleviative efficacy in the dextran sodium sulfate (DSS)-induced enterocolitis model in vivo by modulating the pro-inflammatory behavior of innate immune cells including macrophages and neutrophils, promoting anti-inflammatory cytokine profiles, and downregulating key transcription factors of inflammatory pathways. For enteric delivery of ceria-based anti-inflammatory nanozymes, iron-ceria nanoparticles with lower toxicity and higher catalytic activity are formulated into iron-ceria nanotablets (CFNT). Orally administered CFNT provides therapeutic efficacy on the enterocolitis model in vivo by manipulating the behavior of immune cells, cytokine secretion, and transcription factors toward an anti-inflammatory environment. image-
dc.language영어-
dc.publisherWiley-Blackwell-
dc.titleOrally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease-
dc.typeArticle-
dc.identifier.doi10.1002/adhm.202401994-
dc.citation.journaltitleAdvanced Healthcare Materials-
dc.identifier.wosid001306136900001-
dc.identifier.scopusid2-s2.0-85203087618-
dc.citation.startpage2401994-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
dc.type.docTypeArticle; Early Access-
dc.description.journalClass1-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusOXIDE-
dc.subject.keywordPlusADSORPTION-
dc.subject.keywordPlusRESISTANCE-
dc.subject.keywordAuthoranti-inflammations-
dc.subject.keywordAuthorenteric delivery-
dc.subject.keywordAuthorinflammatory bowel diseases-
dc.subject.keywordAuthoriron-ceria nanoparticles-
dc.subject.keywordAuthornanomedicines-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science

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