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Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage

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dc.contributor.authorSinn, D. I.-
dc.contributor.authorLee, S. T.-
dc.contributor.authorChu, K.-
dc.contributor.authorJung, K. H.-
dc.contributor.authorSong, E. C.-
dc.contributor.authorKim, J. M.-
dc.contributor.authorPark, D. K.-
dc.contributor.authorKim, M.-
dc.contributor.authorRoh, J. K.-
dc.date.accessioned2009-12-24T07:32:59Z-
dc.date.available2009-12-24T07:32:59Z-
dc.date.issued2006-11-25-
dc.identifier.citationNeurosci Lett. 2007 Jan 16;411(3):238-42. Epub 2006 Nov 22.en
dc.identifier.issn0304-3940 (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-4MD9KFJ-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7ece4f0ed6d198fbde77e26cfbd83a78-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17123715-
dc.identifier.urihttps://hdl.handle.net/10371/22329-
dc.description.abstractMemantine, a N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits hematoma expansion and celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces perihematomal inflammation in intracerebral hemorrhage. We examined whether the combination treatment has additive effects in experimental intracerebral hemorrhage (ICH). ICH was induced using stereotaxic infusion of collagenase into brains of adult rats. After the induction of ICH, rats were treated with intraperitoneal injection of memantine (20 mg/kg), celecoxib (20 mg/kg) or both agents. Only vehicles were administrated in rats of the control group. Results showed that the combination treatment of memantine and celecoxib reduced both hematoma volume and brain edema. Combination treatment also induced the better functional recovery with further attenuation of cerebral inflammation and apoptosis compared to the control group. When compared to the single agent groups, the combination treatment showed better effects in neuroprotection and anti-inflammation. These results suggest the feasible combined application of memantine and celecoxib in ICH treatment.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectAnimalsen
dc.subjectAntigens, CD11b/metabolismen
dc.subjectCaspase 3/metabolismen
dc.subjectCerebral Hemorrhage/chemically induced/*drug therapyen
dc.subjectCollagenasesen
dc.subjectDisease Models, Animalen
dc.subjectDrug Therapy, Combinationen
dc.subjectFunctional Lateralityen
dc.subjectIn Situ Nick-End Labeling/methodsen
dc.subjectMaleen
dc.subjectMemantine/*therapeutic useen
dc.subjectNeuroprotective Agents/*therapeutic useen
dc.subjectPyrazoles/*therapeutic useen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectSulfonamides/*therapeutic useen
dc.titleCombined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhageen
dc.typeArticleen
dc.contributor.AlternativeAuthor신동인-
dc.contributor.AlternativeAuthor이순태-
dc.contributor.AlternativeAuthor주건-
dc.contributor.AlternativeAuthor정건화-
dc.contributor.AlternativeAuthor송은철-
dc.contributor.AlternativeAuthor김정민-
dc.contributor.AlternativeAuthor박동규-
dc.contributor.AlternativeAuthor김만호-
dc.contributor.AlternativeAuthor노재규-
dc.identifier.doi10.1016/j.neulet.2006.10.050-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Neuroscience (뇌신경과학전공)Journal Papers (저널논문_뇌신경과학전공)
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