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Expression of uteroglobin in a murine model of allergic rhinitis

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dc.contributor.authorWon, T. B.-
dc.contributor.authorQuan, S. H.-
dc.contributor.authorRhee, C. S.-
dc.contributor.authorMin, Y. G.-
dc.contributor.authorLee, C. H.-
dc.date.accessioned2009-12-24T08:02:38Z-
dc.date.available2009-12-24T08:02:38Z-
dc.date.issued2007-11-21-
dc.identifier.citationActa Otolaryngol Suppl. 2007 Oct;(558):83-9.en
dc.identifier.issn0365-5237 (Print)-
dc.identifier.urihttp://www.informaworld.com/smpp/content~db=all?content=10.1080/03655230701624921-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17882576-
dc.identifier.urihttps://hdl.handle.net/10371/22360-
dc.description.abstractCONCLUSION: We observed for the first time the expression of Uteroglobin (UGB) in the nasal mucosa of mice. The results of our study suggest that UGB may play an important role in the regulation of inflammation in allergic rhinitis (AR) as well as in the lower airway allergic inflammations. OBJECTIVES: Uteroglobin is a protein secreted by epithelial lining of organs communicating with the external environment. Reports of its immunomodulatory effects in allergic disease have been made, but the true physiological role still remains to be elucidated. In this study we tried to observe the expression of UGB in the nasal mucosa of mice and determine its role in AR. MATERIALS AND METHODS: Thirty BALB-c mice at 3 weeks of age (10 mice/group) were sensitized systemically by intraperitoneal ovalbumin injection and locally by ovalbumin inhalation. Control group were sensitized with PBS. Treatment group had intraperitoneal dexamethasone injection 1 hour before the initial sensitization while control and AR group were injected with PBS. Symptom scores, eosinophil counts, immunohistochemical staining as well as UGB mRNA expression in the nasal mucosa and lung tissue were analyzed. RESULTS: The symptom scores and eosinophil counts between control and treatment group was significantly different from the AR group (P<0.01). On immunohistochemical staining, UGB was localized in the epithelium and submucosal gland of the nasal mucosa as well as in the epithelium of respiratory bronchioles. UGB mRNA expression of the nasal mucosa and lung tissue was decreased in the AR group compared to the control group (P=0.022). In the treatment group UGB expression was increased compared to the AR group (P=0.016). The results of IHC and mRNA expression in the lung tissue correlated with the results in the nasal mucosa.en
dc.language.isoen-
dc.publisherScandinavian University Pressen
dc.subjectAnimalsen
dc.subjectAnti-Inflammatory Agents/pharmacologyen
dc.subjectCell Counten
dc.subjectDexamethasone/pharmacologyen
dc.subjectDisease Models, Animalen
dc.subjectEosinophils/metabolismen
dc.subjectFemaleen
dc.subjectImmunohistochemistryen
dc.subjectInjections, Intraperitonealen
dc.subjectLung/metabolismen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectRNA, Messenger/metabolismen
dc.subjectRespiratory Mucosa/*metabolismen
dc.subjectRhinitis, Allergic, Perennial/drug therapy/*metabolismen
dc.subjectUteroglobin/*metabolismen
dc.titleExpression of uteroglobin in a murine model of allergic rhinitisen
dc.typeArticleen
dc.contributor.AlternativeAuthor원태빈-
dc.contributor.AlternativeAuthor이재서-
dc.contributor.AlternativeAuthor민양기-
dc.contributor.AlternativeAuthor이철희-
dc.identifier.doi10.1080/03655230701624921-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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