S-Space College of Medicine/School of Medicine (의과대학/대학원) Immunology (면역학전공) Journal Papers (저널논문_면역학전공)
Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans
- Koh, Y. Y.; Jung da, E.; Koh, J. Y.; Kim, J. Y.; Yoo, Y.; Kim, C. K.
- Issue Date
- Chest. 2007 May;131(5):1454-60.
- Antigens, CD3/metabolism; Antigens, CD8/metabolism; Biopsy; Bronchiolitis Obliterans/*etiology/*pathology; Bronchoalveolar Lavage Fluid/*chemistry/*cytology; Bronchoscopy; Case-Control Studies; Cell Count; Child, Preschool; Female; Humans; Infant; Interleukin-8/*analysis; Lung/immunology/pathology/radiography; Male; Measles/*complications/*pathology; Neutrophils/pathology; T-Lymphocytes/immunology/pathology; Tomography, X-Ray Computed
- BACKGROUND: Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles. METHODS: BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8. RESULTS: BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean +/- SD, 418.6 +/- 286.0 pg/mL) compared to the control group (92.8 +/- 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens. CONCLUSION: These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.
- 0012-3692 (Print)
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