Browse

Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans

Cited 35 time in Web of Science Cited 39 time in Scopus
Authors
Koh, Y. Y.; Jung da, E.; Koh, J. Y.; Kim, J. Y.; Yoo, Y.; Kim, C. K.
Issue Date
2007-05-15
Publisher
American College of Chest Physicians (ACCP)
Citation
Chest. 2007 May;131(5):1454-60.
Keywords
Antigens, CD3/metabolismAntigens, CD8/metabolismBiopsyBronchiolitis Obliterans/*etiology/*pathologyBronchoalveolar Lavage Fluid/*chemistry/*cytologyBronchoscopyCase-Control StudiesCell CountChild, PreschoolFemaleHumansInfantInterleukin-8/*analysisLung/immunology/pathology/radiographyMaleMeasles/*complications/*pathologyNeutrophils/pathologyT-Lymphocytes/immunology/pathologyTomography, X-Ray Computed
Abstract
BACKGROUND: Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles. METHODS: BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8. RESULTS: BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean +/- SD, 418.6 +/- 286.0 pg/mL) compared to the control group (92.8 +/- 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens. CONCLUSION: These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.
ISSN
0012-3692 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17494793

http://hdl.handle.net/10371/22404
DOI
https://doi.org/10.1378/chest.06-0188
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse