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Flow cytometric assessment of anti-neuronal antibodies in central nervous system involvement of systemic lupus erythematosus and other autoimmune diseases

Cited 16 time in Web of Science Cited 21 time in Scopus
Authors
Kang, E. H.; Shen, G. Q.; Morris, R.; Metzger, A.; Lee, E. Y.; Lee, Y. J.; Lee, E. B.; Song, Y. W.
Issue Date
2007-12-20
Publisher
SAGE Publications
Citation
Lupus. 2008;17(1):21-5.
Keywords
Adult*Autoantibodies/blood/cerebrospinal fluidCell Line, TumorCerebrovascular Disorders/immunologyConfusion/immunologyEpilepsy/immunologyFemale*Flow CytometryHeadache Disorders/immunologyHumansLupus Erythematosus, Systemic/complications/*immunologyLupus Vasculitis, Central Nervous System/complications/*immunologyMaleMeningitis, Aseptic/immunologyMiddle AgedNeurons/*immunologyPsychotic Disorders/immunologyRheumatic Diseases/complications/*immunologyUp-Regulation
Abstract
The objective of this study is to evaluate the association between anti-neuronal antibody (anti-NA) and central nervous system (CNS) manifestations of systemic lupus erythematosus (SLE) and other rheumatic diseases using a flow cytometric method. Anti-NA was measured by flow cytometry in serum and cerebrospinal fluid (CSF) samples from patients with SLE (n=44 for serum, n=17 for CSF), other rheumatic diseases (n=64 for serum, n=21 for CSF) and from healthy controls (n=65 for serum, n=18 for CSF). Serum anti-NA was more frequently observed in SLE (31.8%, 14/44) than in other rheumatic diseases (4.7%, 3/64, P<0.001) or in healthy controls (0%, 0/65, P<0.00001). In SLE patients, the frequency of serum anti-NA was significantly higher in CNS-SLE (76.5%, 13/17) than in non CNS-SLE (3.7%, 1/27, P<0.000001). CSF anti-NA was detected in 88.2% (15/17) of CNS-SLE and was more frequently detected in CNS-SLE (15/17, 88.2%) than in other rheumatic diseases with CNS involvement (1/21, 4.8%, P<0.000001) or in healthy controls (0/18, P<0.000001). In conclusion, serum anti-NA was more frequently found in CNS-SLE than in non CNS-SLE, other rheumatic diseases or in healthy controls. The frequency of CSF anti-NA in CNS-SLE was significantly higher than in other rheumatic diseases with CNS involvement or in healthy controls.
ISSN
0961-2033 (Print)
Language
English
URI
http://lup.sagepub.com/cgi/content/abstract/17/1/21

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18089679

http://hdl.handle.net/10371/22538
DOI
https://doi.org/10.1177/0961203307085256
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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