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Perifollicular fibrosis: pathogenetic role in androgenetic alopecia
DC Field | Value | Language |
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dc.contributor.author | Yoo, H. G. | - |
dc.contributor.author | Kim, J. S. | - |
dc.contributor.author | Lee, S. R. | - |
dc.contributor.author | Pyo, H. K. | - |
dc.contributor.author | Moon, H. I. | - |
dc.contributor.author | Lee, J. H. | - |
dc.contributor.author | Kwon, O. S. | - |
dc.contributor.author | Chung, J. H. | - |
dc.contributor.author | Kim, K. H. | - |
dc.contributor.author | Eun, H. C. | - |
dc.contributor.author | Cho, K. H. | - |
dc.date.accessioned | 2009-12-24T09:59:54Z | - |
dc.date.available | 2009-12-24T09:59:54Z | - |
dc.date.issued | 2006-06-07 | - |
dc.identifier.citation | Biol Pharm Bull. 2006 Jun;29(6):1246-50. | en |
dc.identifier.issn | 1347-5215 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16755026 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22553 | - |
dc.description.abstract | Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10(-9)-10(-7) M) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10(-8) M) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-beta1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-beta1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-beta1 antibody (10 microg/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-beta1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-beta1 expression may explain another possible mechanism how finasteride works in AGA. | en |
dc.language.iso | en | en |
dc.publisher | Pharmaceutical Society of Japan | en |
dc.title | Perifollicular fibrosis: pathogenetic role in androgenetic alopecia | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 유현경 | - |
dc.contributor.AlternativeAuthor | 김진숙 | - |
dc.contributor.AlternativeAuthor | 이세라 | - |
dc.contributor.AlternativeAuthor | 표현걸 | - |
dc.contributor.AlternativeAuthor | 문형인 | - |
dc.contributor.AlternativeAuthor | 이종희 | - |
dc.contributor.AlternativeAuthor | 권오상 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.contributor.AlternativeAuthor | 김규한 | - |
dc.contributor.AlternativeAuthor | 은희철 | - |
dc.contributor.AlternativeAuthor | 조광현 | - |
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